Nuclear or cytoplasmic localization of Bag-1 distinctly correlates with pathologic behavior and outcome of gastric carcinomas

Correlation between the expression of the BAG-1 gene and clinicopathologic factors in colorectal cancer

“…A report demonstrated that the expression of Bag-1 mRNA is comparatively higher in gastric carcinoma than in adjacent tissues, which is consistent with data from western blot analysis of gastric carcinoma tissues (Zheng et al 2010). Therefore, upregulated Bag-1 expression might contribute to the malignant transformation of gastric epithelial cells.…”

“…The same study demonstrated that age, depth of invasion, lymphatic invasion, and lymph node metastasis are independent prognostic factors for carcinomas. Inversely, Bag-1 expression is not an independent prognostic factor for carcinomas (Zheng et al 2010).…”

The altered expression of ING5 protein is involved in gastric carcinogenesis and subsequent progression

“…It continues to be a major health concern because of a slow decrease in incidence in Asia and high mortality from diagnosed GC in the West, even though sophisticated diagnostic and operative techniques are widely applied in clinical practice [22,23]. Pathologic and genetic observations demonstrate that gastric dysplasia precedes the majority of carcinoma and could undergo malignant transformation [24,25].…”

Bag-1L is a Stress-withstand Molecule Prevents the Downregulation of Mcl-1 and c-Raf Under Control of Heat Shock Proteins in Cisplatin Treated HeLa Cervix Cancer Cells

“…Bag-1 has a role to inhibit apoptosis via MAPK cascade activating Ras, Raf-1, MEK, ERK signaling molecules. In addition, Bag-1 has been observed in p53 mutant cancer cells and causes suppression of p53-mediated apoptosis (Townsend et al, 2003;Zheng et al, 2010).…”

“…The Bag-1 COOH terminus is also required for interaction and activation of Raf-1, a serine-threonine kinase involved in cell survival and proliferation that provides an alternate potential mechanism by which Bag-1 might promote cell survival. Hsp70 and Raf-1 compete for binding to Bag-1, and high levels of Hsp70 prevent activation of Raf-1 by Bag-1 in hamster fibroblasts, suggesting that growth and/or survival-promoting effects of Bag-1 may be mediated by activation of Raf-1-dependent mitogen-activated protein kinase pathways and negatively regulated by chaperone binding (Zheng et al, 2010). Apart from interactions with Bcl-2, Bag-1 serves as a co-chaperone to Hsp/Hsc70s by interacting with the ATPase domain of these proteins (specifically IB and IIB subdomains) to exchange ADP for ATP under normal and stress conditions, positively affecting the activity of Hsp70 system.…”