2018
DOI: 10.1016/j.jbior.2018.05.001
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Nuclear organization mediates cancer-compromised genetic and epigenetic control

Abstract: Nuclear organization is functionally linked to genetic and epigenetic regulation of gene expression for biological control and is modified in cancer. Nuclear organization supports cell growth and phenotypic properties of normal and cancer cells by facilitating physiologically responsive interactions of chromosomes, genes and regulatory complexes at dynamic three-dimensional microenvironments. We will review nuclear structure/function relationships that include: 1. Epigenetic bookmarking of genes by phenotypic … Show more

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Cited by 10 publications
(5 citation statements)
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References 175 publications
(282 reference statements)
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“…Overall, studies of CT organization and their alterations have potentially important implications for understanding cancer progression and deciphering optimal treatment strategies. Cancer is characterized by compromised global interactions and regulation of the genome . A major challenge in cancer screening is the determination of which patients require aggressive treatment or only to be monitored.…”
Section: Introductionmentioning
confidence: 99%
“…Overall, studies of CT organization and their alterations have potentially important implications for understanding cancer progression and deciphering optimal treatment strategies. Cancer is characterized by compromised global interactions and regulation of the genome . A major challenge in cancer screening is the determination of which patients require aggressive treatment or only to be monitored.…”
Section: Introductionmentioning
confidence: 99%
“…In the interphase nucleus, chromosomes are non-randomly arranged within the nuclear space. They are structurally and functionally organized into territories, and this nuclear organization is generally altered in cancer ( Lever and Sheer, 2010 ; Zaidi et al, 2018 ; Mai, 2019 ). Notably, centromeres occupy particular subnuclear domains in interphase nuclei [review in ( Muller et al, 2019 )].…”
Section: Cenp-a Nuclear Distribution In Health and Cancermentioning
confidence: 99%
“…Chromatin and nuclear organization have long been linked to genome function and cancer [11][12][13][14][15][16]. Thus, the recent capacity to target chromatin and its regulators has broadened possibilities of conventional treatments (chemotherapy, radiotherapy) [17][18][19].…”
Section: Introductionmentioning
confidence: 99%