I review recent progress in the extraction of unpolarized parton distributions in the proton and in nuclei from a unified point of view that highlights how the interplay between high-energy particle physics and lower energy nuclear physics can be of mutual benefit to either field in areas ranging from the search for physics beyond the standard model at the LHC, to the study of the non perturbative structure of nucleons and teh emergence of nuclei from quark and gluon degrees of freedom, to the interaction of colored probes in a cold nuclear medium.