Nuclear Pore Complex

Advances and Breakthroughs in IRES-Directed Translation and Replication of Picornaviruses

“…NPCs have an octahedral orientation across the two folds of the nuclear envelope, similar to bicycle wheel spokes. They have specialized linking proteins called nucleoporins, or Nups ( 159 ). In cells infected with the Sindbis virus (SINV), at 18 h postinfection (hpi), significant upregulation and downregulation of mRNAs were observed in response to viral infection.…”