Nuclear Probes and Intraoperative Gamma Cameras

Heller, Sherman; Zanzonico, Pat

doi:10.1053/j.semnuclmed.2010.12.004

Cited by 113 publications

(59 citation statements)

References 37 publications

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“…These particles have a short range, that is, a few millimeters in soft tissue, and thus particles arising from the injection site will not reach the detector. Because a b-probe needs a minimally collimated and shielded detector, it is suitable for minimal invasive use (11). Because of the short range of the b 1 -particles, however, detailed preoperative anatomic localization is a prerequisite, which may be provided by PET/CT.…”

Section: Discussionmentioning

confidence: 99%

Pilot Study on the Feasibility of PET/CT Lymphoscintigraphy with ⁸⁹Zr-Nanocolloidal Albumin for Sentinel Node Identification in Oral Cancer Patients

et al. 2013

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With conventional imaging techniques such as planar lymphoscintigraphy and SPECT/CT, preoperative sentinel node (SN) identification can be difficult when the SN is near the primary tumor, as is the case in floor-of-mouth carcinomas. PET/CT lymphoscintigraphy may improve the detection and localization of such SNs. Methods: In this study, the clinical feasibility of PET/ CT lymphoscintigraphy using 89 Zr-nanocolloidal albumin was evaluated in 5 oral cancer patients. PET/CT lymphoscintigraphy was performed after peritumoral injection of 89 Zr-nanocolloidal albumin. The routine SN procedure, including SPECT/CT using 99m Tc-nanocolloidal albumin, was performed on the same patients 7-9 d after the injection of 89 Zr-nanocolloidal albumin. Results: Comparison of radiocolloid distribution on PET/CT and SPECT/CT showed identical drainage patterns. Moreover, PET/ CT was able to identify additional foci near the primary tumor. Conclusion: This pilot PET/CT study on SN detection indicated that lymphoscintigraphy using 89 Zr-nanocolloidal albumin is feasible.Key Words: sentinel node; PET/CT; 89 Zr; Nanocoll; head and neck cancer J Nucl Med 2013; 54:585-589 DOI: 10.2967/jnumed.112.115188Sent inel nodes (SNs) near a primary tumor can be hidden by the high amount of radioactivity at the injection site. In such cases, the resolution of planar lymphoscintigraphy and SPECT/CT is limited (1). For oral cancer, this is especially true for tumors located in the floor of the mouth that drain to lingual lymph nodes or level I lymph nodes (2,3), which may explain the significantly lower sensitivity of the SN procedure for floor-of-mouth tumors than for other sites in the oral cavity (80% vs. 97%) (4).PET provides dynamic 3-dimensional information at a higher spatial resolution and, thus, improves anatomic localization-of particular importance in the complex anatomy of the neck, with its abundant lymph nodes (i.e., about 150 on each side). In addition, improved visualization of lymphatic vessels may result in better differentiation between first-and second-echelon lymph nodes. Therefore, we hypothesized that PET might perform better than g-camera-based techniques.Recently, we developed 89 Zr-nanocolloidal albumin for lymphatic mapping and SN detection using PET/CT. The potential of this tracer was shown preclinically in a rabbit lymphogenic metastasis model (5).The present study aimed to evaluate the feasibility of PET/ CT lymphoscintigraphy using 89 Zr-nanocolloidal albumin in patients with early-stage oral cavity carcinoma and to obtain initial clinical experience in a head-to-head comparison with g-camera-based imaging using 99m Tc-nanocolloidal albumin. MATERIALS AND METHODS PatientsThe study included 5 previously untreated patients with earlystage oral cancer who were scheduled for transoral excision and the SN procedure. Each patient had a clinically negative neck as assessed by ultrasound-guided fine-needle aspiration cytology. Three of the patients had a paramedian floor-of-mouth carcinoma, and 2 had a lateral tongue carcinoma. Th...

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Section: Discussionmentioning

confidence: 99%

Pilot Study on the Feasibility of PET/CT Lymphoscintigraphy with ⁸⁹Zr-Nanocolloidal Albumin for Sentinel Node Identification in Oral Cancer Patients

et al. 2013

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“…Böylece hedefin daha doğru belirlenmesi ve hedef/ zemin oranının yükseltilmesi sağlanır (35,36). Teknolojik gelişmeler ile iki-üç boyutlu saptama sağlayan problar da geliştirilmiştir.…”

Section: Sentinel Lenf Bezi Biyopsisinde Kullanılan Cihazlar Agamaprunclassified

“…İntraoperatif kullanım için geliştirilmiş küçük gama kameralarda yarı-iletken kadmiyum tellürid (CdTe) ve kadmiyum çinko tellürid (CdZnTe) kristalleri kullanılabilir (36). Yarı-iletken kristallerin düşük voltajda uzun süre kullanımı polarizasyon fenomeni nedeni ile zaman içerisinde enerji duyarlılığında azalmaya neden olmaktadır.…”

Section: Bi̇ntraoperatifgamakameralarunclassified

Sentinel Lymph Node Biopsy: Actual Approaches

Tuncel¹,

Salancı²,

Bozkurt³

2017

Nts

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Öz Abstract GirişKanser yayılımında en önemli yollardan biri lenfatik yayılımdır. On yedinci yüzyılda lenfatik sistemin tanımlanması ve ardından kanserdeki rolünün saptanmaya başlaması ile bu konuda çeşitli çalışmalar yapılmıştır. Bu araştırmaların sonucunda bugün kanserin yerleştiği bölgeye bağlı olarak önce bölgesel lenf bezlerine ilerlediği ve klinik tanıdan çok daha önce bu bölgesel lenf bezlerinde mikrometastazların gerçekleştiği bilinmektedir. Bu bilgi özellikle meme kanseri ve malign melanom gibi kanserlerde sentinel lenf bezi (SLB) kavramının doğmasını sağlamıştır (1). İlk SLB tanımı Cabanas tarafından penil kanserde yapılmıştır (2). Lenfosintigrafinin SLB saptanmasında kullanılması Chiappa ve ark.'nın 1966'da testiküler kanserlerde yaptığı çalışma ile başlamıştır (3). Morton ve ark.'nın 194 malign melanom hastasında lenfosintigrafi kullanılarak lenfatik yayılımın araştırdığı çalışma SLB'nin örneklemesinin önünü açmış olup, günümüzde SLB sintigrafisi rutin uygulama kılavuzlarında yerini almıştır (4). Meme kanserlerinde de Christensen ve ark. ile başlayan çalışmalar koruyucu meme cerrahisi uygulamalarının yaygınlaşmasına ve hastaların daha az cerrahi komplikasyon ile tedavi edilmelerine olanak vermiştir (5). Son yıllarda gelişen görüntüleme ve intraoperatif deteksiyon teknolojileri sayesinde SLB biyopsisinin (SLBB) başarısı ve kullanım sıklığı

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“…5,6 Analogous to onboard functional and molecular imaging in radiation therapy, beta and gamma emission imaging methods are already utilized in the operating room, often with hand-held detectors. 7 Methods have been developed to generate tomographic, "freehand" SPECT images from multiple poses of a hand-held gamma camera, 8,9 an approach which illustrates the importance of intraoperative tomographic imaging and illustrates the benefits of freeing the detector from a gantry.…”

Section: Introductionmentioning

confidence: 99%

Onboard functional and molecular imaging: A design investigation for robotic multipinhole SPECT

et al. 2013

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Purpose: Onboard imaging-currently performed primarily by x-ray transmission modalities-is essential in modern radiation therapy. As radiation therapy moves toward personalized medicine, molecular imaging, which views individual gene expression, may also be important onboard. Nuclear medicine methods, such as single photon emission computed tomography (SPECT), are premier modalities for molecular imaging. The purpose of this study is to investigate a robotic multipinhole approach to onboard SPECT. Methods: Computer-aided design (CAD) studies were performed to assess the feasibility of maneuvering a robotic SPECT system about a patient in position for radiation therapy. In order to obtain fast, high-quality SPECT images, a 49-pinhole SPECT camera was designed which provides high sensitivity to photons emitted from an imaging region of interest. This multipinhole system was investigated by computer-simulation studies. Seventeen hot spots 10 and 7 mm in diameter were placed in the breast region of a supine female phantom. Hot spot activity concentration was six times that of background. For the 49-pinhole camera and a reference, more conventional, broad field-of-view (FOV) SPECT system, projection data were computer simulated for 4-min scans and SPECT images were reconstructed. Hot-spot localization was evaluated using a nonprewhitening forced-choice numerical observer. Results:The CAD simulation studies found that robots could maneuver SPECT cameras about patients in position for radiation therapy. In the imaging studies, most hot spots were apparent in the 49-pinhole images. Average localization errors for 10-mm-and 7-mm-diameter hot spots were 0.4 and 1.7 mm, respectively, for the 49-pinhole system, and 3.1 and 5.7 mm, respectively, for the reference broad-FOV system. Conclusions: A robot could maneuver a multipinhole SPECT system about a patient in position for radiation therapy. The system could provide onboard functional and molecular imaging with 4-min scan times.

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Nuclear Probes and Intraoperative Gamma Cameras

Cited by 113 publications

References 37 publications

Pilot Study on the Feasibility of PET/CT Lymphoscintigraphy with ⁸⁹Zr-Nanocolloidal Albumin for Sentinel Node Identification in Oral Cancer Patients

Pilot Study on the Feasibility of PET/CT Lymphoscintigraphy with ⁸⁹Zr-Nanocolloidal Albumin for Sentinel Node Identification in Oral Cancer Patients

Sentinel Lymph Node Biopsy: Actual Approaches

Onboard functional and molecular imaging: A design investigation for robotic multipinhole SPECT

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Nuclear Probes and Intraoperative Gamma Cameras

Cited by 113 publications

References 37 publications

Pilot Study on the Feasibility of PET/CT Lymphoscintigraphy with 89Zr-Nanocolloidal Albumin for Sentinel Node Identification in Oral Cancer Patients

Pilot Study on the Feasibility of PET/CT Lymphoscintigraphy with 89Zr-Nanocolloidal Albumin for Sentinel Node Identification in Oral Cancer Patients

Sentinel Lymph Node Biopsy: Actual Approaches

Onboard functional and molecular imaging: A design investigation for robotic multipinhole SPECT

Contact Info

Product

Resources

About

Pilot Study on the Feasibility of PET/CT Lymphoscintigraphy with ⁸⁹Zr-Nanocolloidal Albumin for Sentinel Node Identification in Oral Cancer Patients

Pilot Study on the Feasibility of PET/CT Lymphoscintigraphy with ⁸⁹Zr-Nanocolloidal Albumin for Sentinel Node Identification in Oral Cancer Patients