This work presents the experimental study of the isomeric ratio of 115mCd to 115gCd produced in 116Cd(γ, n)115m,gCd photonuclear reaction and 116Cd(n, γ)115m,gCd neutron capture reaction by thermal, epithermal and mixed thermal and epithermal neutrons. The investigated samples were natural cadmium irradiated at the bremsstrahlung photon flux, in the neutron source constructed at the electron accelerator Microtron MT-25 of the Flerov Laboratory of Nuclear Reaction, Joint Institute for Nuclear Research, Dubna, Russia. The results were analyzed, discussed, compared and combined with those of other authors in the existing literature to examine the role of the nuclear channel effect in the isomeric ratio and provide the nuclear data for theoretical model interpretation of nuclear reactions and applied research.