2012
DOI: 10.1016/j.mce.2011.09.025
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Nuclear receptor HR4 plays an essential role in the ecdysteroid-triggered gene cascade in the development of the hemimetabolous insect Blattella germanica

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Cited by 26 publications
(22 citation statements)
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“…Searching for regulatory factors involved in the temporal control of JH synthesis, we noticed that the timing of BgHMG-S1 and BgHMG-R up-regulation in the nymphal-adult transition correlates well with the decline of the 20E pulse that triggers such transition. We have previously demonstrated that a complex 20E-triggered hierarchy of nuclear receptors, converging in the strong up-regulation of BgFTZ-F1 at the imaginal transition, regulates the imaginal molt323334353637. Consistently, we found that this 20E-induced cascade of nuclear receptors, composed by BgE75A, BgHR3-A, BgHR4 , and BgFTZ-F1 was sequentially expressed also in last nymphal instar CA cells (Fig.…”
Section: Resultssupporting
confidence: 83%
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“…Searching for regulatory factors involved in the temporal control of JH synthesis, we noticed that the timing of BgHMG-S1 and BgHMG-R up-regulation in the nymphal-adult transition correlates well with the decline of the 20E pulse that triggers such transition. We have previously demonstrated that a complex 20E-triggered hierarchy of nuclear receptors, converging in the strong up-regulation of BgFTZ-F1 at the imaginal transition, regulates the imaginal molt323334353637. Consistently, we found that this 20E-induced cascade of nuclear receptors, composed by BgE75A, BgHR3-A, BgHR4 , and BgFTZ-F1 was sequentially expressed also in last nymphal instar CA cells (Fig.…”
Section: Resultssupporting
confidence: 83%
“…Likewise, ectopic overexpression of Svp in larval and pupal stages of D. melanogaster leads to lethality at the onset of metamorphosis due to the impairment of the normal activity of the EcR-USP complex49. In B. germanica , we have shown that the same 20E-triggered hierarchy of nuclear receptors is expressed during nymphal development and controls the metamorphic process, including proper molting36. However, in contrast to holometabolous insects, BgSvp isoforms seem not to be involved in 20E-dependent processes as revealed by the fact that the BgSvp -depleted nymphs developed normally and reached adulthood without any noticeable defect.…”
Section: Discussionmentioning
confidence: 84%
“…Recently, we have shown that a complex 20E-triggered hierarchy of nuclear receptors controls these metamorphic transformations in B. germanica (11,12). The same gene cascade, however, is also present during the previous nymphal-nymphal transitions (12), implying that stage-specific factors modify the responsiveness of target genes during the metamorphic transition. Because metamorphosis requires tissue death and remodeling, we speculated that both types of metamorphic changes could be regulated by the same factor(s) in a coordinated manner.…”
Section: Resultsmentioning
confidence: 95%
“…Conversely, data available in hemimetabolan species are more limited, which is a serious drawback if one aims at comparing the two modes of metamorphosis and at drawing conclusions in evolutionary terms. Concerning the hemimetabolan mode, the best known species is the cockroach Blattella germanica, where the factors operating in the 20E signaling pathway have been extensively studied over the last ten years (Cruz et al, , 2007Maestro et al, 2005;Mane-Padros et al, 2012Martin et al, 2006). More recently, the components of the JH receptor complex, Methoprene tolerant (Met) and Taiman (Tai), as well as Krüppel homolog 1 (Krh1), the master transducer of the JH signal, have been reported in B. germanica in the context of metamorphosis regulation Belles, 2011, 2014;.…”
Section: Introductionmentioning
confidence: 99%