Nuclear Receptors: A Historical Perspective

Mazaira, Gisela Ileana; Zgajnar, Nadia R.; Lotufo, Cecilia Maricel; Daneri-Becerra, Cristina; Sivils, Jeffrey C.; Soto, O. Bonilla; Cox, Marc B.; Galigniana, Mario D.

doi:10.1007/978-1-4939-9195-2_1

Cited by 8 publications

(4 citation statements)

References 17 publications

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“…For any molecule to be used in cell signalling, it needs to be perceived by cells and to initiate a response. For many molecules, this involves a receptor protein, which may be on the cell surface [ 41 ] or in an intracellular compartment, such as the cytoplasm [ 42 ] or nucleus [ 43 ]. Some signalling molecules are perceived by proteins not classed as receptors, such as the effect of NO on soluble guanylyl cyclase (sGC).…”

Section: Downstream Effectsmentioning

confidence: 99%

Downstream Signalling from Molecular Hydrogen

Hancock

Russell

2021

Plants

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Molecular hydrogen (H2) is now considered part of the suite of small molecules that can control cellular activity. As such, H2 has been suggested to be used in the therapy of diseases in humans and in plant science to enhance the growth and productivity of plants. Treatments of plants may involve the creation of hydrogen-rich water (HRW), which can then be applied to the foliage or roots systems of the plants. However, the molecular action of H2 remains elusive. It has been suggested that the presence of H2 may act as an antioxidant or on the antioxidant capacity of cells, perhaps through the scavenging of hydroxyl radicals. H2 may act through influencing heme oxygenase activity or through the interaction with reactive nitrogen species. However, controversy exists around all the mechanisms suggested. Here, the downstream mechanisms in which H2 may be involved are critically reviewed, with a particular emphasis on the H2 mitigation of stress responses. Hopefully, this review will provide insight that may inform future research in this area.

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Section: Downstream Effectsmentioning

confidence: 99%

Downstream Signalling from Molecular Hydrogen

Hancock

Russell

2021

Plants

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“…Известно, что VDR принадлежит к суперсемейству ядерных рецепторов -транскрипционных факторов, которые регулируют экспрессию большого количества генов. Ядерные рецепторы после связывания с лигандами активируются и соединяются в ядре клетки с участками ДНК, локализованными в промоторном регионе таргентных генов [11].…”

Section: рецептор витамина Dunclassified

Genetic and epigenetic factors regulating the expression and function of the vitamin D receptor in patients with coronary artery disease

2021

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Coronary artery disease (CAD) remains the leading cause of death and disability in developed countries. Using traditional risk factors for CAD, it is possible to predict the likelihood of acute coronary events in no more than 50% of cases. Therefore, the study of influence of genetic and epigenetic factors on the development of CAD is extremely important. Research in recent years has shown that vitamin D deficiency is a new risk factor for atherosclerosis and immune inflammation. Vitamin D implements protective effects against immune inflammation through receptors in the vascular wall. A single nucleotide polymorphism of the vitamin D receptor (VDR) gene is a potential risk factor for CAD associated with low vitamin D levels. VDR expression correlates with the expression of pro-inflammatory cytokines and is regulated by microRNAs — microRNA-125a-5p, microRNA-125b-5p, microRNA-214-3p and microRNA-21 These microRNAs regulate the action, synthesis and metabolism of vitamin D and can themselves be influenced by VDR signals through dynamic feedback, which can lead to destabilization of mRNA and inhibition of translation. This literature review highlights the effect of a single nucleotide polymorphism of the VDR gene and microRNA on the pathogenetic mechanisms of CAD.

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“…The fifth subfamily is more concise, constituting the steroidogenic factor-like receptors, NR5A1 and NR5A2. Finally, the sixth category consists solely of receptors not aligned with the preceding subfamilies, designated as the germ cell nuclear factor 1 (GCNF1) [ 39 ]. The NRs basic structure comprises an N-terminal regulatory domain (NTD) featuring the activation function (AF1), a ligand-binding domain (LBD), a DNA-binding domain (DBD), and an intervening hinge region [ 37 , 40 ].…”

Section: Introductionmentioning

confidence: 99%

Exploring the nexus of nuclear receptors in hematological malignancies

Manickasamy,

Sajeev,

BharathwajChetty

et al. 2024

Cell. Mol. Life Sci.

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Hematological malignancies (HM) represent a subset of neoplasms affecting the blood, bone marrow, and lymphatic systems, categorized primarily into leukemia, lymphoma, and multiple myeloma. Their prognosis varies considerably, with a frequent risk of relapse despite ongoing treatments. While contemporary therapeutic strategies have extended overall patient survival, they do not offer cures for advanced stages and often lead to challenges such as acquisition of drug resistance, recurrence, and severe side effects. The need for innovative therapeutic targets is vital to elevate both survival rates and patients' quality of life. Recent research has pivoted towards nuclear receptors (NRs) due to their role in modulating tumor cell characteristics including uncontrolled proliferation, differentiation, apoptosis evasion, invasion and migration. Existing evidence emphasizes NRs' critical role in HM. The regulation of NR expression through agonists, antagonists, or selective modulators, contingent upon their levels, offers promising clinical implications in HM management. Moreover, several anticancer agents targeting NRs have been approved by the Food and Drug Administration (FDA). This review highlights the integral function of NRs in HM's pathophysiology and the potential benefits of therapeutically targeting these receptors, suggesting a prospective avenue for more efficient therapeutic interventions against HM. Graphical abstract

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Nuclear Receptors: A Historical Perspective

Cited by 8 publications

References 17 publications

Downstream Signalling from Molecular Hydrogen

Downstream Signalling from Molecular Hydrogen

Genetic and epigenetic factors regulating the expression and function of the vitamin D receptor in patients with coronary artery disease

Exploring the nexus of nuclear receptors in hematological malignancies

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