Nuclear Receptors in Health and Diseases

Abstract

Nuclear receptors (NRs) are a vital superfamily of transcription factors that play crucial roles in physiology and pharmacology [...]

Sulfation of chondroitin and bile acids converges to antagonize Wnt/β-catenin signaling and inhibit APC deficiency-induced gut tumorigenesis

“…Bile acids are common substrates of sulfation, and sulfoconjugation controls bile acid homeostasis by impacting bile acid elimination and detoxification 37 . Meanwhile, activation of the bile acid sensing nuclear receptor FXR has been shown to inhibit gut tumorigenesis 38 , 39 , 40 . Compared to Apc Δgut - Het mice, Apc Δgut - Het Papss2 Δgut mice showed increased levels of total bile acids in the serum ( Fig.…”