2024
DOI: 10.1136/gutjnl-2023-331741
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Nuclear receptors: pathophysiological mechanisms and drug targets in liver disease

Vanessa Dubois,
Philippe Lefebvre,
Bart Staels
et al.

Abstract: Nuclear receptors (NRs) are ligand-dependent transcription factors required for liver development and function. As a consequence, NRs have emerged as attractive drug targets in a wide range of liver diseases. However, liver dysfunction and failure are linked to loss of hepatocyte identity characterised by deficient NR expression and activities. This might at least partly explain why several pharmacological NR modulators have proven insufficiently efficient to improve liver functionality in advanced stages of d… Show more

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