Nuclear Respiratory Factor 1 Overexpression Inhibits Proliferation and Migration of PC3 Prostate Cancer Cells

Wu, Chun‐Hsien; Hsieh, Pei-Fang; Lee, Yen-Hsi; Kuo, Wade Wei-Ting; Wu, Richard C.; Lin, Yung-Yao; Hung, Cheng‐Chieh; Hsieh, Ming-Lin; Pang, See‐Tong; Yang, Yu‐Lin; Lin, Victor C.

doi:10.21873/cgp.20346

Cited by 7 publications

(5 citation statements)

References 20 publications

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“…3F ). Peroxisome proliferator-activated receptor-γ co-activator 1α (PGC-1α), nuclear respiratory factor 1 (NRF-1), and estrogen-related receptor alpha (ERRα) are the vital regulators for mitochondrial biogenesis [ 44 , 45 ]. Consistent with reduced ATP, protein levels of PCG-1α, NRF-1, and ERRα were decreased in DM-αKG-treated cells (Fig.…”

Section: Resultsmentioning

confidence: 99%

α-KG inhibits tumor growth of diffuse large B-cell lymphoma by inducing ROS and TP53-mediated ferroptosis

Cai

Lü

et al. 2023

Cell Death Discov.

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Metabolic reprogramming is a hallmark of human malignancies. Dysregulation of glutamine metabolism is essential for tumorigenesis, microenvironment remodeling, and therapeutic resistance. Based on the untargeted metabolomics sequencing, we identified that the glutamine metabolic pathway was up-regulated in the serum of patients with primary DLBCL. High levels of glutamine were associated with inferior clinical outcomes, indicative of the prognostic value of glutamine in DLBCL. In contrast, the derivate of glutamine alpha-ketoglutarate (α-KG) was negatively correlated with the invasiveness features of DLBCL patients. Further, we found that treatment with the cell-permeable derivative of α-KG, known as DM-αKG, significantly suppressed tumor growth by inducing apoptosis and non-apoptotic cell death. Accumulation of a-KG promoted oxidative stress in double-hit lymphoma (DHL), which depended on malate dehydrogenase 1 (MDH1)-mediated 2-hydroxyglutarate (2-HG) conversion. High levels of reactive oxygen species (ROS) contributed to ferroptosis induction by promoting lipid peroxidation and TP53 activation. In particular, TP53 overexpression derived from oxidative DNA damage, further leading to the activation of ferroptosis-related pathways. Our study demonstrated the importance of glutamine metabolism in DLBCL progression and highlighted the potential application of α-KG as a novel therapeutic strategy for DHL patients.

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Section: Resultsmentioning

confidence: 99%

α-KG inhibits tumor growth of diffuse large B-cell lymphoma by inducing ROS and TP53-mediated ferroptosis

Cai

Lü

et al. 2023

Cell Death Discov.

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“…However, study also reported that NRF1 might inhibit tumor progression in some speci c cancer types. NRF1 suppresses TGF-β signaling and inhibits the proliferation and migration of PC3 prostate cancer cells (12).…”

Section: Discussionmentioning

confidence: 99%

“…In contrast to these ndings, NRF1 was also reported to act as a tumor suppressor. It suppresses transforming growth factor β (TGF-β) signaling and inhibits the proliferation and migration of PC3 prostate cancer cells (12). NRF1 also regulates the expression of autophagy related 5 (ATG5) and autophagy related 7 (ATG7) and inhibits the migration of melanoma cells (13).…”

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confidence: 99%

Nuclear Respiratory Factor 1 Drives Hepatocellular Carcinoma Progression by Forming a Positive Feedback Loop with LPCAT1-ERK1/2-CREB Axis

et al. 2023

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“…NRF1 suppresses TGF-β signaling and inhibits the proliferation and migration of PC3 prostate cancer cells. [ 12 ] Besides, NRF1 regulates the expression of autophagy related 5 (ATG5) and autophagy related 7 (ATG7) and inhibits the migration of melanoma cells. [ 13 ] Therefore, the function of NRF1 is complex and may play different roles in tumor progression depending on specific tumor types.…”

Section: Discussionmentioning

confidence: 99%

“…It suppresses transforming growth factor β (TGF-β) signaling and inhibits the proliferation and migration of PC3 prostate cancer cells. [ 12 ] NRF1 also regulates the expression of autophagy related 5 (ATG5) and autophagy related 7 (ATG7) and inhibits the migration of melanoma cells. [ 13 ] Thus, NRF1 is not only a mitochondrial biogenesis stimulator but also a transcription factor that is involved in multiple cellular activities.…”

Section: Introductionmentioning

confidence: 99%

Nuclear respiratory factor 1 drives hepatocellular carcinoma progression by activating LPCAT1-ERK1/2-CREB axis

Liu,

Yin,

Zhao

et al. 2023

Biol Direct

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Background Nuclear respiratory factor 1 (NRF1) is a transcription factor that participates in several kinds of tumor, but its role in hepatocellular carcinoma (HCC) remains elusive. This study aims to explore the role of NRF1 in HCC progression and investigate the underlying mechanisms. Results NRF1 was overexpressed and hyperactive in HCC tissue and cell lines and high expression of NRF1 indicated unfavorable prognosis of HCC patients. NRF1 promoted proliferation, migration and invasion of HCC cells both in vitro and in vivo. Mechanistically, NRF1 activated ERK1/2-CREB signaling pathway by transactivating lysophosphatidylcholine acyltransferase 1 (LPCAT1), thus promoting cell cycle progression and epithelial mesenchymal transition (EMT) of HCC cells. Meanwhile, LPCAT1 upregulated the expression of NRF1 by activating ERK1/2-CREB signaling pathway, forming a positive feedback loop. Conclusions NRF1 is overexpressed in HCC and promotes HCC progression by activating LPCAT1-ERK1/2-CREB axis. NRF1 is a promising therapeutic target for HCC patients.

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Nuclear Respiratory Factor 1 Overexpression Inhibits Proliferation and Migration of PC3 Prostate Cancer Cells

Cited by 7 publications

References 20 publications

α-KG inhibits tumor growth of diffuse large B-cell lymphoma by inducing ROS and TP53-mediated ferroptosis

α-KG inhibits tumor growth of diffuse large B-cell lymphoma by inducing ROS and TP53-mediated ferroptosis

Nuclear Respiratory Factor 1 Drives Hepatocellular Carcinoma Progression by Forming a Positive Feedback Loop with LPCAT1-ERK1/2-CREB Axis

Nuclear respiratory factor 1 drives hepatocellular carcinoma progression by activating LPCAT1-ERK1/2-CREB axis

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