Nuclear Spin-Lattice Relaxation Measurements by Tone-Burst Modulation

Simulating the effect of input errors on the accuracy of Tofts’ pharmacokinetic model parameters

“…When using the latter, the calculation of the native T 1 of the tissue (T 10 ) is required and the relation between T 1 and concentration should be known. T 10 maps can be calculated using different techniques, such as the variable flip angle [32] or the Look-Locker [33] sequence. The theoretical relation between the contrast agent concentration and the signal depends on the MR sequence used for the DCE-MRI acquisition.…”

Simultaneous estimation of T1 and the flip angle in hyperpolarized NMR experiments using acquisition at non-regular time intervals

“…An early general method proposed for estimating T 1 is the 'single-scan Fourier transform' (SSFT) pulse sequence of Look and Locker [32,33] that was developed further by Kaptein et al [34]; and it turns out (see below) to have relevance in estimating T 1 in modern DNP experiments. A single p pulse is first applied to invert M z , and this is followed by a series of equally spaced (s) small-flipangle pulses, a.…”

Single‐shot measurement of solids and liquids T1 values by a small‐angle flip‐flop pulse sequence

“…Look and Locker (LL) proposed the use of small angle pulses for solid and liquid samples with the sequence (π − τ – [ θ − τ 1 −] n ) where θ ≤ π/2, albeit compromising S/N values. Later, Demco et al enhanced the signal amplitude through a flip‐flop pulse sequence (FFS) (π − τ − [{π/2} x − τ – {π/2} −x − τ 1 ] n ), where the addition of a (π/2) −x pulse induces the return of the magnetization vector to the longitudinal axis, in a similar fashion to magnetization‐conserving sequences.…”