Nuclear Structure and Decay Data for A=149 Isobars

Singh, Balraj

doi:10.1016/j.nds.2022.10.001

Nuclear Data Sheets

2022

DOI: 10.1016/j.nds.2022.10.001

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Nuclear Structure and Decay Data for A=149 Isobars

Balraj Singh

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Cited by 2 publications

References 392 publications

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Unraveling the formation of Tb/Pd films by coupled reduction as targets for heavy ion-beam irradiation

Cerboni,

Szekér,

Dressler

et al. 2025

Journal of Alloys and Compounds

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Unraveling the formation of Tb/Pd films by coupled reduction as targets for heavy ion-beam irradiation

Cerboni,

Szekér,

Dressler

et al. 2025

Journal of Alloys and Compounds

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Terbium-149 production: a focus on yield and quality improvement towards preclinical application

Favaretto,

Grundler,

Talip

et al. 2024

Sci Rep

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Terbium-149 (T1/2 = 4.1 h, Eα = 3.98 MeV (16.7%), 28 µm range in tissue) is a radionuclide with potential for targeted alpha therapy. Due to the negligible emission of α-emitting daughter nuclides, toxicity to healthy tissue may be reduced in comparison with other α-particle emitters. In this study, terbium-149 was produced via 1.4 GeV proton irradiation of a tantalum target at the CERN-ISOLDE facility. The spallation products were mass separated and implanted on zinc-coated foils and, later, radiochemically processed. Terbium-149 was separated from the co-produced isobaric radioisotopes and the zinc coating from the implantation foil, using cation-exchange and extraction chromatographic techniques, respectively. At the end of separation, up to 260 MBq terbium-149 were obtained with > 99% radionuclidic purity. Radiolabeling experiments were performed with DOTATATE, achieving 50 MBq/nmol apparent molar activity with radiochemical purity > 99%. The chemical purity was determined by inductively coupled plasma–mass spectrometry measurements, which showed lead, copper, iron and zinc only at ppb level. The radiolabeling of the somatostatin analogue DOTATATE with [149Tb]TbCl3 and the subsequent in vivo PET/CT scans conducted in xenografted mice, showing good tumor uptake, further demonstrated product quality and its ability to be used in a preclinical setting.

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Nuclear Structure and Decay Data for A=149 Isobars

Cited by 2 publications

References 392 publications

Unraveling the formation of Tb/Pd films by coupled reduction as targets for heavy ion-beam irradiation

Unraveling the formation of Tb/Pd films by coupled reduction as targets for heavy ion-beam irradiation

Terbium-149 production: a focus on yield and quality improvement towards preclinical application

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