Nuclear survivin expression correlates with endoglin-assessed microvascularisation in laryngeal carcinoma

Marioni, Gino; Ottaviano, Giancarlo; Marchese‐Ragona, Rosario; Fasanaro, Elena; Tealdo, Giulia; Zanotti, Claudia; Randon, Benedetto; Giacomelli, Luciano; Stellini, Edoardo; Blandamura, Stella

doi:10.1136/jclinpath-2016-204230

Cited by 10 publications

(10 citation statements)

References 21 publications

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“…Univariate Cox regression analysis identified high nuclear Survivin expression, plus key clinicopathologic factors, including histological grade (G3‐4), vessel invasion, N1 stage, and without the ACT, as predictors of poor prognosis. The survival results support the above ones and those by Xie et al Previously, the positive associations of nuclear Survivin and aggressive phenotypes, such as cell proliferation and microvascular density (MVD) and/or poor prognosis, were also revealed by many papers in many malignant tumors . In vitro investigations showed that nuclear Survivin play its oncogenic role via many molecular mechanisms, such as abrogation of cell‐cycle checkpoints, an increase of DNA repair capacity, and activation of nuclear factor κB (NF‐κB) p65, in cancer cells .…”

Section: Discussionsupporting

confidence: 83%

“…The survival results support the above ones and those by Xie et al 26 Previously, the positive associations of nuclear Survivin and aggressive phenotypes, such as cell proliferation and microvascular density (MVD) and/or poor prognosis, were also revealed by many papers in many malignant tumors. [34][35][36][37] In vitro investigations showed that nuclear Survivin play its oncogenic role via many molecular mechanisms, such as abrogation of cell-cycle checkpoints, an increase of DNA repair capacity, and activation of F I G U R E 3 Prognostic value of nuclear Survivin expression in subgroups of pancreatic ductal adenocarcinoma. A, Male patients (log-rank test; P = 0.0129); B, nondiabetic patients (log-rank test; P = 0.0344); C, patients with head-located tumors (log-rank test; P = 0.0264); D, patients with G1-2 tumors (log-rank test; P = 0.0206).…”

Section: Univariate Cox Regression Analysis Identified High Nuclear Smentioning

confidence: 99%

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High nuclear Survivin expression as a poor prognostic marker in pancreatic ductal adenocarcinoma

Zhou

Lü

Zeng

et al. 2018

Journal of Surgical Oncology

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Background Survivin, one of the key regulators of mitosis and apoptosis, has long been well recognized to play important biological roles in many neoplasms, including pancreatic ductal adenocarcinoma (PDAC). However, its prognostic value in PDAC remains controversial. Patients and Methods Nuclear expression of Survivin was detected, using tissue microarray‐based immunohistochemistry, in paired‐tumor and nontumor samples from 306 patients with radically resected PDAC. The staining H scores were further correlated with clinicopathologic features and disease‐specific survival (DSS). Results Nuclear Survivin expression was much higher in tumor than in nontumor tissues (P < 0.001). No significant association between tumoral Survivin expression and clinicopathologic variables was found. For prognosis, high Survivin expression was associated with shortened DSS in all eligible patients and four subgroups, that is, male and nondiabetic patients as well as those with head‐located and G1‐2 tumors, shown by univariate analyses. In addition, a statistically marginal significance was revealed in eight subgroups. For the entire cohort and two subgroups, nuclear Survivin expression was also multivariate identified as an independent predictor for DSS. For patients with G1‐2 tumors, it was the single prognostic marker. Conclusion Our data suggest an association between high nuclear Survivin expression and poor prognosis in PDAC. However, further confirmation might be necessary.

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Section: Discussionsupporting

confidence: 83%

Section: Univariate Cox Regression Analysis Identified High Nuclear Smentioning

confidence: 99%

High nuclear Survivin expression as a poor prognostic marker in pancreatic ductal adenocarcinoma

Zhou

Lü

Zeng

et al. 2018

Journal of Surgical Oncology

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“…In our study endoglin was one of the proteins affected by RT in HNSCC patients. Functionally endoglin is involved in angiogenesis and intratumoral endoglin level is an important marker of tumor angiogenesis and neovascularization process [33,34]. Both intratumoral endoglin expression and circulating endoglin levels were correlated with therapy response and long-term prognosis [35,36].…”

Section: Discussionmentioning

confidence: 99%

Radiotherapy-Induced Changes in the Systemic Immune and Inflammation Parameters of Head and Neck Cancer Patients

Balázs

Kis

Badie

et al. 2019

Cancers

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Though radiotherapy is a local therapy, it has systemic effects mainly influencing immune and inflammation processes. This has important consequences in the long-term prognosis and therapy individualization. Our objective was to investigate immune and inflammation-related changes in the peripheral blood of head and neck cancer patients treated with radiotherapy. Peripheral blood cells, plasma and blood cell-derived RNA were isolated from 23 patients before and at two time points after radiotherapy and cellular immune parameters, plasma protein changes and gene expression alterations were studied. Increased regulatory T cells and increased CTLA4 and PD-1 expression on CD4 cells indicated an immune suppression induced by the malignant condition, which was accentuated by radiotherapy. Circulating dendritic cells were strongly elevated before treatment and were not affected by radiotherapy. Decreased endoglin levels in the plasma of patients before treatment were further decreased by radiotherapy. Expression of the FXDR, SESN1, GADD45, DDB2 and MDM2 radiation-response genes were altered in the peripheral blood cells of patients after radiotherapy. All changes were long-lasting, detectable one month after radiotherapy. In conclusion we demonstrated radiotherapy-induced changes in systemic immune parameters of head and neck cancer patients and proposed markers suitable for patient stratification worth investigating in larger patient cohorts.

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“…The main strength of our investigation lies in the homogeneity of the patient population since: (i) all patients underwent surgery; (ii) their surgical treatment was performed consecutively by the same team; (iii) only squamous cell carcinomas located in the larynx were considered; (iv) for each case, both biopsies and surgical specimens were assessed and compared; (v) both CD105 and CD31 were used to assess MVD; (vi) clinical-radiological follow-up criteria were defined; (vii) a tailored multivariable statistical model was used to analyze the variables potentially predictive of DFS. In addition, over the course of about 15 years [23], the pathologists in our research group have gained plenty of experience of assessing MVD from the immunohistochemical expression of CD105 in head and neck malignancies [24], also in association with oncogenes [25], or tumor suppressors [26]. The main weaknesses of our study concern the retrospective setting and the limited number of cases considered.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of CD105- and CD31-Assessed Microvessel Density in Paired Biopsies and Surgical Samples of Laryngeal Carcinoma

Marioni

Franz

Ottaviano

et al. 2020

Cancers

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Small pretreatment laryngeal biopsies may not fully represent a tumor’s biological profile. This study on laryngeal squamous cell carcinoma (LSCC) aimed to investigate the prognostic role of CD105- and CD31-assessed microvessel density (MVD) in paired biopsies and surgical specimens and the association and discrepancy between CD105- and CD31-assessed MVD in biopsies and surgical specimens. CD105- and CD31-assessed MVD was analyzed in paired biopsies and surgical specimens of 45 consecutive cases of LSCC. In the LSCC biopsies and surgical specimens, median CD105-assessed MVD was significantly higher in N+ than in N0 cases (p = 0.0008, and p = 0.0002, respectively). Disease-free survival (DFS) was associated with CD105- and CD31-assessed MVD in both biopsies and surgical specimens (p < 0.0001 for all specimens). Multivariable Cox’s regression showed that pathological grade (p < 0.0001) and CD105-assessed MVD in LSCC biopsies (p = 0.0209) predicted DFS. Lin’s concordance coefficient showed that CD31 overestimated MVD compared with CD105 in LSCC biopsies and surgical specimens. CD105-assessed MVD should be further investigated in larger LSCC series as a potential prognostic marker for identifying: patients at higher risk of recurrence who might warrant more aggressive therapy; and cN0 patients requiring elective neck dissection for a significant risk of regional metastasis.

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Nuclear survivin expression correlates with endoglin-assessed microvascularisation in laryngeal carcinoma

Cited by 10 publications

References 21 publications

High nuclear Survivin expression as a poor prognostic marker in pancreatic ductal adenocarcinoma

High nuclear Survivin expression as a poor prognostic marker in pancreatic ductal adenocarcinoma

Radiotherapy-Induced Changes in the Systemic Immune and Inflammation Parameters of Head and Neck Cancer Patients

Prognostic Significance of CD105- and CD31-Assessed Microvessel Density in Paired Biopsies and Surgical Samples of Laryngeal Carcinoma

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