Nucleated red blood cells as marker for an increased risk of unfavorable outcome and mortality in very low birth weight infants

Cremer, Malte; Roll, Stephanie; Graf, C; Weimann, Andreas; Bührer, Christoph; Dame, Christof

doi:10.1016/j.earlhumdev.2015.06.004

Cited by 28 publications

(24 citation statements)

References 24 publications

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“…Underlying mechanisms include maternal hypertension or pre-eclampsia associated with acute or chronic placental insufficiency, which may occur with neonatal neutropenia [29]. Early-onset thrombocytopenia may coincide with high numbers of circulating nucleated red blood cells due to stress erythropoiesis [30]. The shift towards increased erythropoiesis leads to a consecutively decreased megakaryo-and/ or granulopoiesis.…”

Section: Early-onset Thrombocytopeniamentioning

confidence: 99%

Thrombocytopenia and platelet transfusion in the neonate

Cremer

Sallmon

Kling

et al. 2016

Seminars in Fetal and Neonatal Medicine

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Section: Early-onset Thrombocytopeniamentioning

confidence: 99%

Thrombocytopenia and platelet transfusion in the neonate

Cremer

Sallmon

Kling

et al. 2016

Seminars in Fetal and Neonatal Medicine

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“…Furthermore, probiotic-treated pigs had higher postinfection NRBC counts. NRBCs are another cell population that has been associated with septicemia (45). It has been shown that, in addition to promoting a Th1 response through increased IFN-γ production, bLf can also increase the IL-12-to-IL-10 ratio in LPS-stimulated splenocytes to promote the Th1 response (46).…”

Section: Discussionmentioning

confidence: 99%

Dietary Bovine Lactoferrin Reduces Staphylococcus aureus in the Tissues and Modulates the Immune Response in Piglets Systemically Infected with S. aureus

Reznikov¹,

Comstock

Hoeflinger

et al. 2018

Current Developments in Nutrition

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BackgroundBovine lactoferrin (bLf) reduces Staphylococcus aureus infection in premature infants and promotes the growth of Bifidobacterium infantis, a predominant infant gut species. We hypothesized that bLf in combination with B. infantis would reduce the severity of systemic S. aureus infection.ObjectiveThe aim was to determine the effects of oral administration of bLf and B. infantis on the course of systemic S. aureus infection.MethodsColostrum-deprived piglets were fed formulas containing 4 g whey/L (CON group) or bLf (LF group). One-half of the piglets in each group were gavaged with B. infantis (109 colony-forming units/d), resulting in 2 additional groups (BI or COMB, respectively). On day 7, piglets were intravenously injected with S. aureus. Blood samples were collected preinfection and every 12 h postinfection for immune analyses. Tissue samples were collected on day 12 for analysis of bacterial abundance and gene expression.ResultsPreinfection, LF piglets had lower serum interleukin 10 (IL-10), a higher percentage of lymphocytes, and a lower percentage of neutrophils than BI or COMB piglets. After infection, dietary bLf increased piglet weight gain, reduced staphylococcal counts in the kidneys, and tended to lower staphylococcal counts in the lungs and heart. Dietary bLf also decreased kidney IL-10 and increased lung interferon γ (IFN-γ) mRNA. B. infantis increased splenic IFN-γ expression. Renal Toll-like receptor 2 was upregulated in BI piglets but not in COMB piglets. Postinfection, BI piglets had increased serum IL-10 and decreased memory T cell populations. LF and COMB piglets had fewer circulating monocytes and B cells than CON or BI piglets.ConclusionsDietary bLf and B. infantis produced independent and tissue-specific effects. Piglets fed bLf alone or in combination with B. infantis mounted a more effective immune response and exhibited lower bacterial abundance. This study provides biological underpinnings to the clinical benefits of bLf observed in preterm infants but does not support B. infantis administration during S. aureus infection.

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“…12 Elevated nucleated red blood cells (NRBC) are predictive of mortality in very low birth weight infants. 13 Foetal erythropoiesis is regulated by complex mechanisms due to physiologically low oxygen partial pressure in utero in contrast to erythropoiesis after birth. 14 While the role of regulation in bone marrow activity for all cell lines has not yet been evaluated in CDH infants, data from an animal model indicate that erythropoietin (EPO) as a progenitor to red cell differentiation is impaired in CDH.…”

Section: Introductionmentioning

confidence: 99%

Haematopoietic alterations in neonates with congenital diaphragmatic hernia receiving extracorporeal membrane oxygenation support

et al. 2019

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Background Extracorporeal membrane oxygenation procedure (ECMO) has been established in the therapy of respiratory insufficient infants with congenital diaphragmatic hernia. In congenital diaphragmatic hernia newborns, a delay in transfer to an ECMO centre is associated with a sharp increase in mortality. Predictive factors for ECMO support are urgently needed. We evaluated the routine parameters of the first blood withdrawal after birth in congenital diaphragmatic hernia infants, hypothesizing that early signs in bone marrow affecting haematology parameters for early regulation of potentially post birth hypoxia are predictive factors for ECMO support. Materials and methods In 44 patients born with congenital diaphragmatic hernia, differential blood cell count from the first blood withdrawal after birth was examined. Descriptive statistics included median, 95% confidence intervals, minimum and maximum differentiating ECMO/early mortality vs. no ECMO. Odds ratios with CI were calculated by binary logistic regression analysis. Best predictive markers were further checked in combination with the liver-up situation in two factorial regression models. Results In our cohort, the survival rate was 77.3% (34/44). While 18 neonates received ECMO support, 26 experienced no ECMO during hospital stay. Odds ratio calculations showed that risk for ECMO support increases with augmenting leukocytes, erythrocytes, haemoglobin, haematocrit, mean cell volume and absolute immature granulocytes. Further, the risk advanced in line with the severity of congenital diaphragmatic hernia assessed by prenatal ultrasound. Conclusions We conclude that these parameters are associated with disease severity in congenital diaphragmatic hernia newborns and may be considered potentially predictive biomarkers for the necessity of ECMO support.

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Nucleated red blood cells as marker for an increased risk of unfavorable outcome and mortality in very low birth weight infants

Cited by 28 publications

References 24 publications

Thrombocytopenia and platelet transfusion in the neonate

Thrombocytopenia and platelet transfusion in the neonate

Dietary Bovine Lactoferrin Reduces Staphylococcus aureus in the Tissues and Modulates the Immune Response in Piglets Systemically Infected with S. aureus

Haematopoietic alterations in neonates with congenital diaphragmatic hernia receiving extracorporeal membrane oxygenation support

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