Nucleated Red Blood Cells in Preterm Infants With Retinopathy of Prematurity

Lubetzky, Ronit; Stolovitch, Chaim; Dollberg, Shaul; Mimouni, Francis; Salomon, Mazal; Mandel, Dror

doi:10.1542/peds.2005-0915

Cited by 27 publications

(24 citation statements)

References 31 publications

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“…Our data showed no difference in the severity of RDS and ANRBC counts between the two groups [2,3,29] . This indicates that the surfactant therapy and fetal hypoxia were similar in our groups of patients, and contributes little to the development of ROP.…”

Section: Discussioncontrasting

confidence: 64%

Erythrocyte Anti-Oxyenzyme Activity in Preterm Infants with Retinopathy of Prematurity

Chiu²,

Chiang³

et al. 2007

Neonatology

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Background: Retinopathy of prematurity (ROP) is the main cause of visual impairment in premature infants and is considered to be a multifactorial disease. Because of the similarity between the human retina and the erythrocyte concerning their antioxidant mechanism, the aim of this study was to measure the erythrocyte anti-oxyenzyme activity of preterm infants. Methods: This prospective study was performed on a tertiary referral hospital. Blood samples were collected from umbilical arterial lines or the radial artery of 33 preterm infants within 24 h after delivery to evaluate erythrocyte anti-oxyenzyme activity. Clinical data and oxygen administration were obtained and the correlations of enzyme activity and ROP status were examined. Results: Gestational age, birth weight, 1-min Apgar score, and cellular glutathione peroxidase activity were significantly lower in preterm infants with ROP. There was no correlation between enzyme activity and gestational age, birth weight, or severity of ROP. There were no differences in cumulative oxygen and ventilator administration. Conclusions: Gestational age and birth weight, 1-min Apgar score, and glutathione peroxidase activity are risk factors for ROP. Defective glutathione peroxidase activity may contribute to the initial phase of ROP.

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Section: Discussioncontrasting

confidence: 64%

Erythrocyte Anti-Oxyenzyme Activity in Preterm Infants with Retinopathy of Prematurity

Chiu²,

Chiang³

et al. 2007

Neonatology

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“…Reports by Green et al [4] and Buonocore et al [5] demonstrated that high NRBC counts in neonates were an index of perinatal brain damage. Following their lead, others also reported an association between high NRBC counts and adverse outcomes, including cerebral palsy, periventricular leukomalacia, IVH, and ROP [11][12][13][14][15] . We observed that neonates who, on the day of birth, had NRBC exceeded the 95th percentile for age had fourfold higher odds of developing severe IVH and ROP.…”

Section: Discussionmentioning

confidence: 99%

Reference Ranges for Blood Concentrations of Nucleated Red Blood Cells in Neonates

et al. 2010

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Background: Previous studies reported a relationship between high nucleated red blood cells (NRBC) in neonates and the development of intraventricular hemorrhage (IVH) and/or retinopathy of prematurity (ROP). Objective: We sought to (1) establish reference ranges for NRBC in neonates based on a large data set, (2) compare NRBC from automated versus manual counts, (3) determine the effect of an elevated NRBC, on the day of birth, on the odds of developing grade ≧3 IVH or ROP. Methods: We analyzed all NRBC obtained during 8.5 years in a multihospital system, displaying the 5th and 95th percentile limits according to gestational age and postnatal age. Results: NRBC counts were retrieved from 61,932 neonates, 26,536 of which were excluded from the data set. Comparing 9,000 samples run simultaneously on manual versus automated methods, the manual counts yielded slightly higher counts, but the difference is likely insignificant clinically. Altitude of the birth hospital did not correlate with NRBC, and no correlations were observed with cord pH or 1- or 5-min Apgar. An NRBC count >95th percentile limit was associated with higher odds of developing a grade ≧3 IVH (OR 4.28; 95% CI 3.17–5.77) and grade ≧3 ROP (OR 4.18; 95% CI 2.74–6.38). Conclusion: The figures of this report display reference ranges for NRBC according to gestational age and postnatal age. An NRBC count above the 95% limit at birth is associated with a higher risk of subsequently developing severe IVH and severe ROP. We speculate that this association is because an elevated NRBC count is a marker for prenatal hypoxia.

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“…Its main function is erythrocyte maturation and differentiation. 14 Lubetzky et al 15 have shown that neonates with increased absolute neonatal nucleated red blood cells have an increased chance of developing ROP compared with match control and it is possible that rHuEPO contributes to ROP through increased erythropoiesis. Non-erythroid functions of EPO include neurotrophic, neuroprotection, 16 and regulation of angiogenesis.…”

Section: Discussionmentioning

confidence: 99%

The effect of erythropoietin on the severity of retinopathy of prematurity

Kandasamy

Kumar

Hartley

2014

Eye

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Aims Exogenous human erythropoietin (EPO) artificially synthesised through recombinant DNA technology (rHuEPO) is currently used as a substitute for blood transfusion in preterm and low birth weight neonates. The objective of this study is to determine whether the use of rHuEPO is associated with an increased severity of retinopathy of prematurity (ROP) in preterm neonates. Method This retrospective review studies neonates who were admitted to a tertiary perinatal unit and screened for ROP during the 10-year period from January 2003 to December 2012. Results During the 10-year period, 688 preterm neonates underwent ROP screening, with 198 identified as having ROP. The incidence of stage 1 ROP was 51.5% (102/198), followed by 35.9% (71/198) for stage 2, and 12.6% (25/198) for stage 3 and greater. Plus disease was seen in 14 neonates (7.1%). Treatment (laser photocoagulation) was administered in 64% of neonates (16/25) with stage 3 of the disease and above because of progression to threshold ROP. Twenty-six (13%) of the neonates received rHuEPO treatment. There were no statistically significant differences in birth weight (910.4 vs 885 g; P ¼ 0.71), gestational age (26.5 vs 25.8 weeks; P ¼ 0.09), and duration of ventilation (512 vs 501.4 h; P ¼ 0.92) between neonates who did not receive rHuEPO compared with those who were treated with rHuEPO. Multivariate regression analysis showed that the use of EPO was associated with increased severity of ROP.Conclusions EPO therapy appears to increase the risk of development and worsening of ROP.

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Nucleated Red Blood Cells in Preterm Infants With Retinopathy of Prematurity

Cited by 27 publications

References 31 publications

Erythrocyte Anti-Oxyenzyme Activity in Preterm Infants with Retinopathy of Prematurity

Erythrocyte Anti-Oxyenzyme Activity in Preterm Infants with Retinopathy of Prematurity

Reference Ranges for Blood Concentrations of Nucleated Red Blood Cells in Neonates

The effect of erythropoietin on the severity of retinopathy of prematurity

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