Nucleation behavior investigation of cinnamic acid in pure organic solvents: Induction time, metastable zone width and molecular dynamics simulations

Lu, Xuechun; Yan, Yizhen; Zhang, Qi; Cui, Xiujian; Liang, Ruili; Zhang, Xiangyang

doi:10.1016/j.molliq.2024.124143

Cited by 3 publications

(1 citation statement)

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“…24 As the nucleation process of a substance is often affected by the selection of solvent, comparison of the nucleation behaviors in different solvents has been an important research issue. 25–35 In this study, the induction time and MSZW for INA in various solvents, including methanol, acetone, acetonitrile, and ethyl acetate, were experimentally measured under various conditions. The interfacial energy and pre-exponential factor for INA in each solvent obtained from the MSZW were compared with those obtained from the induction time.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the interfacial energy and pre-exponential factor for isonicotinamide in various solvents from the induction time and metastable zone width data

Shiau

2024

CrystEngComm

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Section: Introductionmentioning

confidence: 99%

Comparison of the interfacial energy and pre-exponential factor for isonicotinamide in various solvents from the induction time and metastable zone width data

Shiau

2024

CrystEngComm

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An integral model for determining the temperature-dependent interfacial energy and pre-exponential factor during the metastable zone width cooling process

Shiau

2024

Journal of Molecular Liquids

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Thiourea Nucleation Behavior Investigation Based on Metastable Zone Width and Applied for Continuous Crystallization Designing

Zhou,

Liu,

Lin

et al. 2024

Ind. Eng. Chem. Res.

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Batch crystallization of thiourea has been industrially employed for decades. However, studies of the continuous crystallization and nucleation mechanism of industrial thiourea, especially in the presence of synthesis-related impurities, remain scarce. Herein, the nucleation mechanism of industrial thiourea was investigated under varying conditions. Results revealed that the nucleation constant decreased with increasing saturation temperature, signifying a progressive acceleration in the nucleation rate. Notably, when the saturation temperature surpassed 301 K, the nucleation mechanism shifted from progressive to instantaneous. Furthermore, both the critical nucleation size and critical Gibbs free energy decreased as the saturation temperature rose. Leveraging these insights, a continuous crystallization apparatus was designed, which was experimentally validated to maintain operational stability and achieved a target product purity of 79 wt %, compared to 40 wt % from batch crystallization. These findings offer significant implications for optimizing the crystallization process of industrial thiourea.

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Nucleation behavior investigation of cinnamic acid in pure organic solvents: Induction time, metastable zone width and molecular dynamics simulations

Cited by 3 publications

References 63 publications

Comparison of the interfacial energy and pre-exponential factor for isonicotinamide in various solvents from the induction time and metastable zone width data

Comparison of the interfacial energy and pre-exponential factor for isonicotinamide in various solvents from the induction time and metastable zone width data

An integral model for determining the temperature-dependent interfacial energy and pre-exponential factor during the metastable zone width cooling process

Thiourea Nucleation Behavior Investigation Based on Metastable Zone Width and Applied for Continuous Crystallization Designing

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