Nucleic Acid Contents of Various Organs in Rats During Postnatal Growth

Fujii, Tomoko; Koyama, Ryoshu

doi:10.1507/endocrj1954.9.66

Cited by 8 publications

(1 citation statement)

References 3 publications

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“…The DNA levels were, however, slightly lower than those of previous reports (Fujii & Koyama, 1962;Desjardins, MacMillan & Hafs, 1968;Knox, 1972 (Hartree & Srivastava, 1965) and would contribute to sialic acid levels in the testis, spermatozoa do not enter the epididymis until puberty.…”

Section: Discussioncontrasting

confidence: 72%

Changes in the composition of the excurrent duct system of the rat testis during postnatal development

Brooks¹

1976

Reproduction

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Summary. The gross composition of the testicular excurrent duct system of the rat was examined and compared along the length of the duct and with samples of testis, bladder and liver. Changes in composition with age were examined by analysing tissue from animals at postnatal ages of 19, 36, 48, 60, 90 and 120 The concentration of calcium and magnesium in the excurrent duct system was not significantly different from those levels found in the liver.High levels of spermine and spermidine were confirmed in the prostate, and were also detected in the testis, caput epididymidis and cauda epididymidis, but at a much lower concentration.

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Section: Discussioncontrasting

confidence: 72%

Changes in the composition of the excurrent duct system of the rat testis during postnatal development

Brooks¹

1976

Reproduction

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Reproductive organ DNA and RNA of male and female rats from birth to 100 days of age

1968

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Male and female rats were adjusted to six pups per litter and weaned at 20 days of age. Groups of ten males were killed at five-to ten-day intervals between one and 100 days of age and groups of 12 to 45 females were killed between ten and 100 days. Accumulation with age of gonadal, seminal vesicular, and uterine weight, DNA, and RNA, were compared with body growth in relative growth analyses to delimit puberty and quantify reproductive growth.Males and females possessed similar body growth to 40 days, after which age females grew more slowly while males continued rapid growth to 60 days. Relative to body growth, testes grew more rapidly from ten days whereas ovarian growth generally paralleled body growth until 50 days of age. A shift in gonadal RNA/DNA ratio from less than to greater than unity occurred early in puberty in both sexes. Nucleic acid contents of accessory reproductive organs indicated that effective levels of gonadal steroids promote pubertal growth beginning at about 40 days in males and about 33 days of age in females. These marked pubertal growths ended at 70 days in males and 60 days of age in females.

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A new non-hormonal antifertility drug DL-204: I. Effects on testes and accessory glands of reproduction in male rats

Prasad

Vijayan

1987

Contraception

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The effect of DL-204, 2-(3-ethoxyphenyl)-5,6-dihydro-5-triazole (5,1a)-isoquinoline, a non-hormonal post-implantational anti-fertility drug, on tissue weights, nucleic acids and total protein concentrations in the testes, ventral prostate and seminal vesicles were evaluated in immature and sexually mature rats, while changes in DNA synthesis were studied only in the immature rats. Treatment of 21-day-old rats at doses of 5mg and 10mg/kg bw once daily for 15 days had no effect on body weight but reduced the weights of testes and accessory glands of reproduction. The concentration of DNA increased while RNA and protein decreased significantly. Treatment of adult rats with DL-204 at a dose of 10mg/kg bw had no effect on body and testes weights but reduced ventral prostate and seminal vesicle weights. The concentration of RNA and protein decreased significantly, while DNA concentration was not altered. DL-204 treatment resulted in drastic decrease of RNA/DNA ratio, reflecting ribosomal loss and cytoplasmic shrinkage. The effects observed after DL-204 treatment are comparable to post-castration changes. DL-204 may be acting on testes and accessory reproductive organs by blocking androgen biosynthesis and/or by antagonizing the action of androgens. It may be acting directly on the normal function of the hypothalamo-pituitary-gonadal axis.

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Nucleic Acid Contents of Various Organs in Rats During Postnatal Growth

Cited by 8 publications

References 3 publications

Changes in the composition of the excurrent duct system of the rat testis during postnatal development

Changes in the composition of the excurrent duct system of the rat testis during postnatal development

Reproductive organ DNA and RNA of male and female rats from birth to 100 days of age

A new non-hormonal antifertility drug DL-204: I. Effects on testes and accessory glands of reproduction in male rats

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