Nucleic Acid/Organic Polymer Hybrid Materials: Synthesis, Superstructures, and Applications

Kwak, Minseok; Herrmann, Andreas

doi:10.1002/anie.200906820

Cited by 146 publications

(52 citation statements)

References 162 publications

(177 reference statements)

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“…While pristine DNA assemblies almost exclusively rely on Watson-Crick base pairing, nanostructures from DNA hybrid materials are formed by covalent bonds either to an inorganic core or to a hydrophobic polymer. Various core structures are known that served as anchoring points like Au [94], Ag [95], Fe 3 O 4 [96], CdSe [97], or hydrophobic polymers [98][99][100].…”

Section: Delivery With Scaffolds Consisting Of Nucleic Acids Combinedmentioning

confidence: 99%

Drug delivery systems based on nucleic acid nanostructures

Vries

Zhang

Herrmann

2013

Journal of Controlled Release

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a b s t r a c t a r t i c l e i n f oThe field of DNA nanotechnology has progressed rapidly in recent years and hence a large variety of 1D-, 2D-and 3D DNA nanostructures with various sizes, geometries and shapes is readily accessible. DNA-based nanoobjects are fabricated by straight forward design and self-assembly processes allowing the exact positioning of functional moieties and the integration of other materials. At the same time some of these nanosystems are characterized by a low toxicity profile. As a consequence, the use of these architectures in a biomedical context has been explored. In this review the progress and possibilities of pristine nucleic acid nanostructures and DNA hybrid materials for drug delivery will be discussed. For the latter class of structures, a distinction is made between carriers with an inorganic core composed of gold or silica and amphiphilic DNA block copolymers that exhibit a soft hydrophobic interior.

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Section: Delivery With Scaffolds Consisting Of Nucleic Acids Combinedmentioning

confidence: 99%

Drug delivery systems based on nucleic acid nanostructures

Vries

Zhang

Herrmann

2013

Journal of Controlled Release

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“…More recently, DNA has been functionalized with hydrophobic moieties, such as alkyl chains or polymers, which impart the hybrids with an amphiphilic character. The resulting amphiphiles self‐assemble into micelles, vesicles, and membrane structures like lipids in the cell . In this way, additional information is added to DNA besides its sequence content.…”

Section: Introductionmentioning

confidence: 99%

Sequence‐specific nucleic acid mobility using a reversible block copolymer gel matrix and DNA amphiphiles (lipid‐DNA) in capillary and microfluidic electrophoretic separations

et al. 2015

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Reversible noncovalent but sequence-dependent attachment of DNA to gels is shown to allow programmable mobility processing of DNA populations. The covalent attachment of DNA oligomers to polyacrylamide gels using acrydite-modified oligonucleotides has enabled sequence-specific mobility assays for DNA in gel electrophoresis: sequences binding to the immobilized DNA are delayed in their migration. Such a system has been used for example to construct complex DNA filters facilitating DNA computations. However, these gels are formed irreversibly and the choice of immobilized sequences is made once off during fabrication. In this work, we demonstrate the reversible self-assembly of gels combined with amphiphilic DNA molecules, which exhibit hydrophobic hydrocarbon chains attached to the nucleobase. This amphiphilic DNA, which we term lipid-DNA, is synthesized in advance and is blended into a block copolymer gel to induce sequence-dependent DNA retention during electrophoresis. Furthermore, we demonstrate and characterize the programmable mobility shift of matching DNA in such reversible gels both in thin films and microchannels using microelectrode arrays. Such sequence selective separation may be employed to select nucleic acid sequences of similar length from a mixture via local electronics, a basic functionality that can be employed in novel electronic chemical cell designs and other DNA information-processing systems.

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“…DNA block copolymers and lipid-DNA) is also an effective approach for the assembly of DNA nanostructures [61][62][63][64][65][66]. Liu et al [67] introduced a hydrophobic DNA-surfactant complex in an organic phase for nucleic acid modification and polymerization, producing various amphiphile-DNA nanostructures and DNA side chain polymers.…”

Section: Assembly Of Dna Nanostructuresmentioning

confidence: 99%

Bio-surface engineering with DNA scaffolds for theranostic applications

et al. 2018

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Biosensor design is important to bioanalysis yet challenged by the restricted target accessibility at the biomolecule-surface (bio-surface). The last two decades have witnessed the appearance of various "art-like" DNA nanostructures in one, two, or three dimensions, and DNA nanostructures have attracted tremendous attention for applications in diagnosis and therapy due to their unique properties (e.g., mechanical flexibility, programmable control over their shape and size, easy and high-yield preparation, precise spatial addressability and biocompatibility). DNA nanotechnology is capable of providing an effective approach to control the surface functionality, thereby increasing the molecular recognition ability at the biosurface. Herein, we present a critical review of recent progress in the development of DNA nanostructures in one, two and three dimensions and highlight their biological applications including diagnostics and therapeutics. We hope that this review provides a guideline for bio-surface engineering with DNA nanostructures.

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Nucleic Acid/Organic Polymer Hybrid Materials: Synthesis, Superstructures, and Applications

Abstract: Reviews 8574 www.angewandte.org

Cited by 146 publications

References 162 publications

Drug delivery systems based on nucleic acid nanostructures

Drug delivery systems based on nucleic acid nanostructures

Sequence‐specific nucleic acid mobility using a reversible block copolymer gel matrix and DNA amphiphiles (lipid‐DNA) in capillary and microfluidic electrophoretic separations

Bio-surface engineering with DNA scaffolds for theranostic applications

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