Nucleic acids biosensors based on metal-organic framework (MOF): Paving the way to clinical laboratory diagnosis

Osman, Diaa; El‐Sheikh, Said M.; Sheta, Sheta M.; Ali, Omnia; Salem, A.M.S.; Shousha, Wafaa Gh.; El‐Khamisy, Sherif F.; Shawky, Sherif M.

doi:10.1016/j.bios.2019.111451

Cited by 105 publications

(41 citation statements)

References 118 publications

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“…An area in diagnostics that makes use of reticular framework nanoparticles is that of sensing, specifically for laboratory diagnostics, e.g., in the detection of DNA/RNA or bacterial infections. Reticular framework nanoparticles have been used for a wide variety of sensing applications in diagnostics ranging from metal ions [431] to nucleic acid polymers [432] and all the way to entire organisms such as bacteria. [433] A selection of them will be presented in the following.…”

Section: Nanoparticles As Sensorsmentioning

confidence: 99%

“…Reticular framework nanoparticles have also been used as sensors for nucleic acids. [432] Three different detection techniques have been employed: fluorescence, electrochemistry, and colorimetry. Most assays are based on fluorescence turn-on mechanisms.…”

Section: Nanoparticles As Sensorsmentioning

confidence: 99%

“…This technique has been used with ZIF and MOF nanoparticles. [432] Examples are ZIF-8, [437] which has been used to detect HIV-DNA, and MIL-88B, which could discriminate single-point mutations in DNA. [438] Various extensions of the fluorescence method have been designed to enhance the performance, such as additional amplification by hybridization chain reaction [439] and to extend it for detection of RNA.…”

Section: Nanoparticles As Sensorsmentioning

confidence: 99%

“…[442] However, due to the limited electrical conductivity of MOFs, this method is so far limited to nanocomposites with MOFs as catalysts and other components that enhance the conductivity. [432] The third method for nucleic acid detection with reticular frameworks uses colorimetry. Here, a composite of MIL-88(Fe) and Au nanoparticles catalyzes a reaction, which is silenced by addition of the probe strand.…”

Section: Nanoparticles As Sensorsmentioning

confidence: 99%

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The Chemistry of Reticular Framework Nanoparticles: MOF, ZIF, and COF Materials

Ploetz

Engelke

Lächelt

et al. 2020

Adv Funct Materials

230

145

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Nanoparticles have become a vital part of a vast number of established processes and products; they are used as catalysts, in cosmetics, and even by the pharmaceutical industry. Despite this, however, the reliable and reproducible production of functional nanoparticles for specific applications remains a great challenge. In this respect, reticular chemistry provides methods for connecting molecular building blocks to nanoparticles whose chemical composition, structure, porosity, and functionality can be controlled and tuned with atomic precision. Thus, reticular chemistry allows for the translation of the green chemistry principle of atom economy to functional nanomaterials, giving rise to the multifunctional efficiency concept. This principle encourages the design of highly active nanomaterials by maximizing the number of integrated functional units while minimizing the number of inactive components. State-ofthe-art research on reticular nanoparticles-metal-organic frameworks, zeolitic imidazolate frameworks, and covalent organic frameworks-is critically assessed and the beneficial features and particular challenges that set reticular chemistry apart from other nanoparticle material classes are highlighted. Reviewing the power of reticular chemistry, it is suggested that the unique possibility to efficiently and straightforwardly synthesize multifunctional nanoparticles should guide the synthesis of customized nanoparticles in the future.

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Section: Nanoparticles As Sensorsmentioning

confidence: 99%

Section: Nanoparticles As Sensorsmentioning

confidence: 99%

Section: Nanoparticles As Sensorsmentioning

confidence: 99%

Section: Nanoparticles As Sensorsmentioning

confidence: 99%

See 2 more Smart Citations

The Chemistry of Reticular Framework Nanoparticles: MOF, ZIF, and COF Materials

Ploetz

Engelke

Lächelt

et al. 2020

Adv Funct Materials

230

145

View full text Add to dashboard Cite

show abstract

“…Detection results in vivo will be totally different from detection in vitro. In future, more attention could be focused on the following aspects: (i) the development of water‐stable and low toxic MOFs useful for potential clinical applications of DNA–MOFs as biosensors; and (ii) besides currently developed detection methods, more facile and reasonable approaches are needed to prepare smart biosensors based on DNA–MOFs …”

Section: Conclusion and Future Prospectsmentioning

confidence: 99%

Recent advances in fluorescence sensors based on DNA–MOF hybrids

Cao

et al. 2020

Luminescence

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In this review, the recent advances in the development of fluorescence sensors based on DNA and metal-organic framework hybrids have been reported for nucleic acid, metal ion and amino acid detection. The main detection mechanism depends on different adsorption capacities of MOFs towards different DNA structures (single-stranded DNA, double-stranded DNA), and consequently the fluorescence intensity of probe DNA is changed. These results might open up a way to study their potential application in material science and clinical diagnosis of some related diseases. K E Y W O R D S DNA, fluorescence, metal-organic frameworks, sensor

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Metal–Organic Frameworks as Enzyme Mimics

Liebing¹,

Kulak²

2021

Encyclopedia of Inorganic and Bioinorganic Chemistry

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In this article we are presenting the design of metal–organic frameworks (MOFs) for applications as enzyme mimics (artificial enzymes). MOFs have been the topic of current and intense research for various applications ranging from gas storage, catalysis, to sensing. Their biocatalytic activity, however, has been discovered and investigated only recently—literature exists only for the past decade. High stability also at harsh conditions, low cost, and activity that can be tailored are advantages that compete oftentimes lower activity in comparison to the natural enzymes. Among the nanomaterials with enzymatic activity (nanozymes), MOFs are of special potential, since it is possible to mimic not only the active site of an enzyme but also its microenvironment. We firstly introduce MOFs along with synthetic strategies and secondly give an overview of their nanozymatic activity for oxidation and hydrolytic reactions. This activity has found many applications in biosensing and biomedicine, which are presented in the last chapter of this article. Medicinal applications cover cancer and antimicrobial therapy.

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Nucleic acids biosensors based on metal-organic framework (MOF): Paving the way to clinical laboratory diagnosis

Cited by 105 publications

References 118 publications

The Chemistry of Reticular Framework Nanoparticles: MOF, ZIF, and COF Materials

The Chemistry of Reticular Framework Nanoparticles: MOF, ZIF, and COF Materials

Recent advances in fluorescence sensors based on DNA–MOF hybrids

Metal–Organic Frameworks as Enzyme Mimics

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