2023
DOI: 10.26434/chemrxiv-2023-70gws
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Nucleobase catalysts for the enzymatic activation of 8-oxoguanine DNA glycosylase 1

Emily C. Hank,
Nicholas D'Arcy-Evans,
Olov Wallner
et al.

Abstract: Bifunctional DNA glycosylases employ an active site lysine or the N-terminus to form a Schiff base with the abasic site base excision repair intermediate. For the 8-oxoguanine DNA glycosylase 1 (OGG1), cleaving this reversible structure is the rate-determining step in the initiation of 8-oxoguanine (8-oxoG) repair in DNA. Evolution has led OGG1 to use a productassisted catalysis approach, where the excised 8-oxoG acts as a Brønsted base for cleavage of a Schiff base intermediate. However, the physicochemical p… Show more

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