2015
DOI: 10.1074/jbc.m115.637280
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Nucleolar GTP-binding Protein-1 (NGP-1) Promotes G1 to S Phase Transition by Activating Cyclin-dependent Kinase Inhibitor p21Cip1/Waf1

Abstract: Background: Breast cancer autoantigen nucleolar GTP-binding protein-1 (NGP-1) is overexpressed in cancers. Results: NGP-1 promotes G 1 to S phase transition by modulating the p53/p21 pathway. Conclusion: CDK inhibitor, p21, enhances cell proliferation in certain situations. Significance: This study provides evidence that p21 induces cell proliferation in addition to its traditional tumor suppressor function.

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Cited by 19 publications
(23 citation statements)
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“…These GTPases are found to be shuttling between nucleolus, nucleus and cytoplasm 5 , 6 . Depletion of GNL2, GNL3 and GNL3L has shown to alter G1/S and G2/M cell cycle transition indicates their role in cell cycle regulation 7 9 but the molecular mechanism yet to be defined.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…These GTPases are found to be shuttling between nucleolus, nucleus and cytoplasm 5 , 6 . Depletion of GNL2, GNL3 and GNL3L has shown to alter G1/S and G2/M cell cycle transition indicates their role in cell cycle regulation 7 9 but the molecular mechanism yet to be defined.…”
Section: Introductionmentioning
confidence: 99%
“…GNL3L and GNL3 (nucleostemin) are localized in the nucleolus and modulate ribosomal as well as non-ribosomal pathways 15 21 to promote cell proliferation. Several reports suggest that a functional interaction of GNL family members with large and small ribosomal proteins 7 , 8 , 20 but the functional consequences of these interactions are poorly understood. Studies are warranted to understand whether GNL1 participates in ribosomal biogenesis or has some non-ribosomal functions to regulate cell proliferation during tumorigenesis.…”
Section: Introductionmentioning
confidence: 99%
“…NOG2 —a GTPase—is involved in the regulation of G1 to S phase transition (Datta et al 2015) and ribosomal biogenesis (Essers et al 2014). NOG2 induces cell proliferation by increasing TP53 (and its downstream product, CDKN1A/p21) protein levels, and decreasing RPL23A protein levels (Datta et al 2015). Interest in NOG2 arose from the observation that the protein is overexpressed in some cancers, such as breast or colorectal (Racevskis et al 1996).…”
Section: Resultsmentioning
confidence: 99%
“…NOG2 induces P53 activation by inhibiting RPL23A (60S ribosomal protein L23a), a ribosomal protein that triggers p53 degradation via Mdm2. P53 expression leads to the expression of the cyclin-dependent kinase inhibitor p21 (Datta et al 2015), which is required for the formation of the cyclin D1-CDK4 complex. At higher concentrations, p21 inhibits the cyclin D1-CDK4 complex (LaBaer et al 1997).…”
Section: Resultsmentioning
confidence: 99%
“…MTT assay, RT-qPCR, and Western blotting were performed as described previously (50). Primers used for RT-qPCR are listed in Table S1.…”
Section: Chip-pcrmentioning
confidence: 99%