Nucleolar protein TAAP1/C22orf46confers pro-survival signaling in non-small cell lung cancer
Marietta Döring,
Melanie Brux,
Maciej Paszkowski-Rogacz
et al.
Abstract:Tumor cells subvert immune surveillance or lytic stress by harnessing inhibitory signals. Hence, bispecific antibodies have been developed to direct CTLs to the tumor site and foster immune-dependent cytotoxicity. Although applied with success, T cell–based immunotherapies are not universally effective partially because of the expression of pro-survival factors by tumor cells protecting them from apoptosis. Here, we report a CRISPR/Cas9 screen in human non-small cell lung cancer cells designed to identify gene… Show more
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