Nucleolar Proteins and Cancer: The Roles of Aurora A-Interacting Nucleolar Proteins in Mitosis and Cancer

Iyer, Jyoti; Moghe, Saili; Furukawa, Megumi; Tsai, Ming Ying

doi:10.1007/978-94-007-5818-6_14

Cited by 1 publication

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“…The Aurora kinases play numerous, distinct roles during mitosis: Aurora A regulates mitotic entry, centrosome maturation, and spindle formation while Aurora B participates in multiple mitotic events as a member of the chromosomal passenger complex (for reviews, see Carmena, Ruchaud & Earnshaw, ; Iyer et al , ). Remarkably, D. discoideum has a single Aurora kinase with characteristics of both Aurora A and Aurora B (Li et al , ).…”

Section: Nucleocytoplasmic Translocations During Mitosis In Dictyostementioning

confidence: 99%

Nucleocytoplasmic protein translocation during mitosis in the social amoebozoan Dictyostelium discoideum

O’Day

Budniak

2014

Biological Reviews

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Mitosis is a fundamental and essential life process. It underlies the duplication and survival of all cells and, as a result, all eukaryotic organisms. Since uncontrolled mitosis is a dreaded component of many cancers, a full understanding of the process is critical. Evolution has led to the existence of three types of mitosis: closed, open, and semi-open. The significance of these different mitotic species, how they can lead to a full understanding of the critical events that underlie the asexual duplication of all cells, and how they may generate new insights into controlling unregulated cell division remains to be determined. The eukaryotic microbe Dictyostelium discoideum has proved to be a valuable biomedical model organism. While it appears to utilize closed mitosis, a review of the literature suggests that it possesses a form of mitosis that lies in the middle between truly open and fully closed mitosis-it utilizes a form of semi-open mitosis. Here, the nucleocytoplasmic translocation patterns of the proteins that have been studied during mitosis in the social amoebozoan D. discoideum are detailed followed by a discussion of how some of them provide support for the hypothesis of semi-open mitosis.

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Section: Nucleocytoplasmic Translocations During Mitosis In Dictyostementioning

confidence: 99%

Nucleocytoplasmic protein translocation during mitosis in the social amoebozoan Dictyostelium discoideum

O’Day

Budniak

2014

Biological Reviews

View full text Add to dashboard Cite

show abstract

Nucleolar Proteins and Cancer: The Roles of Aurora A-Interacting Nucleolar Proteins in Mitosis and Cancer

Cited by 1 publication

References 109 publications

Nucleocytoplasmic protein translocation during mitosis in the social amoebozoan Dictyostelium discoideum

Nucleocytoplasmic protein translocation during mitosis in the social amoebozoan Dictyostelium discoideum

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