Nucleolar stress in Drosophila melanogaster

James, Allison; Cindass, Renford; Mayer, Dana; Terhoeve, Stephanie; Mumphrey, Courtney

doi:10.4161/nucl.23944

Cited by 21 publications

(16 citation statements)

References 51 publications

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“…Nopp140 is in structure and function related to Treacle, representing an essential gene in the ribosomopathy syndrome Treacher Collins syndrome (TCS) (Valdez et al, 2004; Sakai and Trainor, 2009; Dai et al, 2016). Depletion of the nucleolar phosphoprotein Nopp140 in the imaginal wing disks of Drosophila results in nucleolar stress, loss of ribosomes and p53-independent apoptosis (James et al, 2013). Since there are no detectible levels of MDM2, NPM/B23 and ARF in Drosophila , the authors conclude that an alternative nucleolar stress response might exist.…”

Section: Nucleolar Factors and Nucleolar Stress In The Regulation Of mentioning

confidence: 99%

Emerging Role of the Nucleolar Stress Response in Autophagy

Pfister

2019

Front. Cell. Neurosci.

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Autophagy represents a conserved self-digestion program, which allows regulated degradation of cellular material. Autophagy is activated by cellular stress, serum starvation and nutrient deprivation. Several autophagic pathways have been uncovered, which either non-selectively or selectively target the cellular cargo for lysosomal degradation. Autophagy engages the coordinated action of various key regulators involved in the steps of autophagosome formation, cargo targeting and lysosomal fusion. While non-selective (macro)autophagy is required for removal of bulk material or recycling of nutrients, selective autophagy mediates specific targeting of damaged organelles or protein aggregates. By proper action of the autophagic machinery, cellular homeostasis is maintained. In contrast, failure of this fundamental process is accompanied by severe pathophysiological conditions. Hallmarks of neuropathological disorders are for instance accumulated, mis-folded protein aggregates and damaged mitochondria. The nucleolus has been recognized as central hub in the cellular stress response. It represents a sub-nuclear organelle essential for ribosome biogenesis and also functions as stress sensor by mediating cell cycle arrest or apoptosis. Thus, proper nucleolar function is mandatory for cell growth and survival. Here, I highlight the emerging role of nucleolar factors in the regulation of autophagy. Moreover, I discuss the nucleolar stress response as a novel signaling pathway in the context of autophagy, health and disease.

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Section: Nucleolar Factors and Nucleolar Stress In The Regulation Of mentioning

confidence: 99%

Emerging Role of the Nucleolar Stress Response in Autophagy

Pfister

2019

Front. Cell. Neurosci.

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“…For example, in Drosophila, RNAi knockdown of NS1, which is the closest homolog of human nucleostemin, inhibits the release of the large ribosomal subunit from the nucleolus, induces loss of adult precursor cells in the midgut epithelium, and retards cell growth in the salivary gland [49]. Loss of Nopp140, which functions as a molecular chaperon for snoRNA [50], disrupts ribosome biogenesis and induces apoptosis in wing discs during larval development [51]. The apoptotic phenotype cannot be rescued by a p53 gene deletion, indicating that depletion of Nopp140 induces apoptosis in a p53-independent manner.…”

Section: Nucleolar Proteins In Developmentmentioning

confidence: 99%

Emerging roles of nucleolar and ribosomal proteins in cancer, development, and aging

Takada

Kurisaki

2015

Cell. Mol. Life Sci.

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Changes in nucleolar morphology and function are tightly associated with cellular activity, such as growth, proliferation, and cell cycle progression. Historically, these relationships have been extensively examined in cancer cells, which frequently exhibit large nucleoli and increased ribosome biogenesis. Recent findings indicate that alteration of nucleolar activity is a key regulator of development and aging. In this review, we have provided evidences that the nucleolus is not just a housekeeping factor but is actively involved in the regulation of cell proliferation, differentiation, and senescence both in vitro and in vivo. In addition, we have discussed how alteration of nucleolar function and nucleolar proteins induces specific physiological effects rather than widespread effects.

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“…, 2016; Russo and Russo, 2017). We hypothesized that if loss of Nipped-A leads to nucleolar stress response, inhibiting differentiation, then Nipped-A– depleted germ cells would have altered nucleolar volume (James et al. , 2013; Falahati et al.…”

Section: Resultsmentioning

confidence: 99%

Tip60 complex promotes expression of a differentiation factor to regulate germline differentiation in femaleDrosophila

McCarthy

Deiulio

Martin

et al. 2018

MBoC

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Germline stem cells (GSCs) self-renew and differentiate to sustain a continuous production of gametes. In the female Drosophila germ line, two differentiation factors, bag of marbles ( bam) and benign gonial cell neoplasm ( bgcn), work in concert in the stem cell daughter to promote the generation of eggs. In GSCs, bam transcription is repressed by signaling from the niche and is activated in stem cell daughters. In contrast, bgcn is transcribed in both the GSCs and stem cell daughters, but little is known about how bgcn is transcriptionally modulated. Here we find that the conserved protein Nipped-A acts through the Tat interactive protein 60-kDa (Tip60) histone acetyl transferase complex in the germ line to promote GSC daughter differentiation. We find that Nipped-A is required for efficient exit from the gap phase 2 (G2) of cell cycle of the GSC daughter and for expression of a differentiation factor, bgcn. Loss of Nipped-A results in accumulation of GSC daughters . Forced expression of bgcn in Nipped-A germline-depleted ovaries rescues this differentiation defect. Together, our results indicate that Tip60 complex coordinates cell cycle progression and expression of bgcn to help drive GSC daughters toward a differentiation program.

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Nucleolar stress in Drosophila melanogaster

Cited by 21 publications

References 51 publications

Emerging Role of the Nucleolar Stress Response in Autophagy

Emerging Role of the Nucleolar Stress Response in Autophagy

Emerging roles of nucleolar and ribosomal proteins in cancer, development, and aging

Tip60 complex promotes expression of a differentiation factor to regulate germline differentiation in femaleDrosophila

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