We derive new positivity bounds on spin-dependent parton distributions in multicolored QCD. They are stronger than Soffer inequality. We check that the new inequalities are stable under one-loop DGLAP evolution to higher normalization points.1. In spite of the vast phenomenological data providing information about the quark and gluon distributions in nucleons we are still far from the complete knowledge of all twist-two distributions, especially of the spindependent ones. Therefore various positivity bounds on parton distributions are very helpful. In particular, an important role is played by Soffer inequality [1] that constraints the transversity quark distribution which is not measured yet. At first sight the set of already known positivity bounds for twist-two distributions is complete and no enhancement can be derived on general grounds without solving the dynamics of QCD. However, if one takes QCD in the limit of large number of colors N c then it is possible to obtain new stronger inequalities.It is well known that in the large N c limit [2] the baryons are described by mean field (Hartree) equations [3], which can be written in terms of bilocal meson fields with all possible spin and isospin quantum numbers. Although the corresponding effective bilocal meson action is not known, a number of results have been obtained for the large N c baryons without specifying the dynamics. Usually these results use the spin-flavor symmetry [4,5] of the solution of the Hartree equation describing the nucleon and ∆ resonance: this solution is invariant under simultaneous space, spin and isospin rotations (but not invariant under a pure flavor rotation). Owing to this spin-flavor symmetry the baryon states (described by this mean field solution) appear as "rotational excitations" with spin S and isospin T connected by constraint S = T [4,5]. In particular, this approach allows to describe nucleon (S = T = 1/2) and ∆ resonance (S = T = 3/2).This picture of the large N c baryons is extensively used in the Skyrme model [6,7] and various chiral quarksoliton models [8]. But some general model-independent results have been extracted for the large N c baryons using only the spin-flavor symmetry [9]. This includes, for example, the identities for the mass splitting of baryons and the large N c classification of spin and isospin structures of various form factors. In this paper we study quark distribution functions relying only on the large N c limit and on the spin-flavor symmetry of the large N c mean field solution.We first present our main result -the new positivity bounds which can be considered as a serious enhancement of the Soffer inequality and then give the derivation and check the stability of the bounds under one-loop the DGLAP evolution.2. Let us first formulate the new positivity bound. At finite number of QCD colors the unpolarized (q f ), longitudinal polarized (∆ L q f ) and transverse polarized (∆ T q f ) quark (antiquark) distributions are known to be constrained by the following set of inequalitiesThe last ineq...