Accurate description of neutrino opacities is central both to the core-collapse supernova (CCSN) phenomenon and to the validity of the explosion mechanism itself. In this work, we study in a systematic fashion the role of a variety of well-selected neutrino opacities in CCSN simulations where multi-energy, three-flavor neutrino transport is solved by the isotropic diffusion source approximation (IDSA) scheme. To verify our code, we first present results from one-dimensional (1D) simulations following corecollapse, bounce, and up to ∼ 250 ms postbounce of a 15M ⊙ star using a standard set of neutrino opacities by Bruenn (1985). Detailed comparison with published results supports the reliability of our three-flavor IDSA scheme using the standard opacity set. We then investigate in 1D simulations how the individual opacity update leads to the difference from the base-line run with the standard opacity set. By making a detailed comparison with previous work, we check the validity of our implementation of each update in a step-by-step manner. Individual neutrino opacities with the largest impact on the overall evolution in 1D simulations are selected for a systematic comparison in our two-dimensional (2D) simulations. Special emphasis is devoted to the criterion of explodability in the 2D models. We discuss the implications of these results as well as the limitations and requirements for future towards more elaborate CCSN modeling.