“…In contrast to their activated counterparts, non-activated aziridines have been evaluated to a limited extent up to now, both from a synthetic and a pharmacological point of view. Due to the presence of an electron-donating substituent at nitrogen, the latter aziridines have to be activated toward aziridinium ion intermediates prior to ring opening [18,19,20,21,22,23,24,25,26,27,28,29,30,31]. Within the present work, the scarcely studied subclass of non-activated 1-alkyl-2-(aminomethyl)aziridines [32,33,34,35,36,37,38,39] was employed as a source of substrates for the development of a novel entry toward the biologically relevant 1,2,3-triaminopropane unit through a highly regioselective and microwave-assisted ring opening by diethylamine in acetonitrile.…”