Nucleophilic C4-selective (hetero) arylation of pyridines for facile synthesis of heterobiaryls
Kewon Kim,
Euna You,
Sungwoo Hong
Abstract:The synthesis of heterobiaryl compounds holds significant value in organic chemistry due to their extensive range of applications. Herein, we report a highly efficient strategy for conducting C4-selective (hetero) arylation of pyridines using N-aminopyridinium salts. The reaction proceeds readily at room temperature in the presence of a base, thus eliminating the requirement for catalysts or oxidants. This method allows for the installation of various electron-rich (hetero) aryl groups on pyridines, resulting … Show more
A practical and general C-4 functionalization strategy of unbiased pyridines is developed by identifying a readily synthesized substituted urea as the pyridine activation reagent.
A practical and general C-4 functionalization strategy of unbiased pyridines is developed by identifying a readily synthesized substituted urea as the pyridine activation reagent.
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