Nucleophilic targets in carcinogenesis, mutagenesis and chemotherapy of cancer

Raikov, Z.; Christova-Georgieva, N.I.; Raikova, E.

doi:10.1016/0306-9877(87)90003-x

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Introduction1

Folic Acid Deficiency and Cancer1

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2004

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“…In the present article we promote our previous concept for the important role of LMN, as the first targets of carcinogenic electrophilic attack, in mutagenesis, carcinogenesis and also -in prevention and treatment of cancer (23). The accumulated epidemiological and experimental data connecting the folate deficiency with cancer risk put the folic acid in the centre of our consideration.…”

Section: Introductionmentioning

confidence: 75%

“…We have investigated the interaction of FA and THFA in vitro with nitrosourea antimutor drugs (Lomustine -CCNU, Carmustine -BCNU), appearing alkylating agents that decompose (in vitro and in vivo) forming electrophilic carbocations (23). The results obtained indicate that FA and THFA interact with the electrophilic agents and that the reactivity of THFA is higher (THFA is alkylated more quickly than FA).…”

Section: Folic Acid Deficiency and Cancermentioning

confidence: 99%

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