Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding atcis-regulatory elements and TAD boundaries

Abstract

The nuclear pore complex (NPC) components, nucleoporins (Nups), have been proposed to mediate spatial and temporal organization of chromatin during gene regulation.Nevertheless, we have little understanding on the molecular mechanisms that underlie Nup-mediated chromatin structure and transcription in mammals. Here, we show that