Nucleoporins in Retroviral Replication

Monette, Anne; Mouland, Andrew J.

doi:10.1016/b978-0-12-811185-7.00003-0

Search citation statements

Order By: Relevance

Paper Sections

Select...

Viral-associated Organelles1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2020

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 352 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is therefore tempting to speculate if the capsid can mimic NTRs like properties to facilitate its nuclear import. Besides the function of escorting viral particles/ components across the pore, FG-Nups were shown to be required for various steps of viral biogenesis, such as integration into the host genome, regulation of transcription, viral replication, assembly and morphogenesis of viral particles and action in host defense evasion [92].…”

Section: Viral-associated Organellesmentioning

confidence: 99%

Multifunctionality of F-rich nucleoporins

Heinß

Sushkin

et al. 2020

Biochemical Society Transactions

View full text Add to dashboard Cite

Nucleoporins (Nups) represent a range of proteins most known for composing the macromolecular assembly of the nuclear pore complex (NPC). Among them, the family of intrinsically disordered proteins (IDPs) phenylalanine-glycine (FG) rich Nups, form the permeability barrier and coordinate the high-speed nucleocytoplasmic transport in a selective way. Those FG-Nups have been demonstrated to participate in various biological processes besides nucleocytoplasmic transport. The high number of accessible hydrophobic motifs of FG-Nups potentially gives rise to this multifunctionality, enabling them to form unique microenvironments. In this review, we discuss the multifunctionality of disordered and F-rich Nups and the diversity of their localizations, emphasizing the important roles of those Nups in various regulatory and metabolic processes.

show abstract

Section: Viral-associated Organellesmentioning

confidence: 99%