Nucleoside ENTry modulates erythropoiesis

Akker, Emile van den

doi:10.1182/blood.2021011474

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Erythropoiesis1

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2023

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“…Due to an increase in erythrocyte hemoglobin, the nucleus becomes inactive and ceases to synthesize DNA or RNA, a process known as nucleus coagulation. The condensation of the nucleus is predominantly attributable to chromatin condensation, 11 a process that begins in primitive adult erythrocytes and concludes in late intermediate and early late juvenile erythrocytes, preparing the nucleus for removal to form reticulocytes in development.…”

Section: Erythropoiesismentioning

confidence: 99%

Molecular regulatory mechanisms of erythropoiesis and related diseases

Zhu

Guo³

et al. 2023

European J of Haematology

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The metabolism of cells and blood circulation allow for the constant production and destruction of red blood cells. Erythrocyte formation allows red blood cells to regenerate, which is crucial for maintaining the equilibrium of the organism. Erythrocyte formation is a multi‐step, intricate process with distinct structural and functional characteristics at each stage. Erythropoiesis is regulated by a number of signaling pathways; malfunctional regulatory mechanisms may result in disease and aberrant erythropoiesis. Therefore, this article focuses on a review of the erythroid formation process, related signaling pathways, and red blood cell lineage diseases.

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Section: Erythropoiesismentioning

confidence: 99%