2018
DOI: 10.25135/acg.oc.35.17.12.055
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Nucleoside substituted perhydro-1λ5-[1,3,2]diazaphospholo[1,5-a]pyridine-1-thione analogues: Synthesis and evaluation of antiviral and antimicrobial activities

Abstract: A new series of nucleoside substituted perhydro-1λ 5 -[1,3,2]diazaphospholo[1,5-a]pyridine-3-thione derivatives 4(a-j) was synthesized by a one-pot two-step process. It involves the formation of key intermediate,-a]pyridine-1-thione (3) and its subsequent reaction with various nucleosides to obtain the title products 4(a-j). Structures of all the newly synthesized compounds were elucidated by spectral analysis. Compound (4b) linked with zidovudine exhibited highest antiviral and antimicrobial activities as com… Show more

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