Nucleotide binding as an allosteric regulatory mechanism for
            <i>Akkermansia muciniphila</i>
            β-
            <i>N</i>
            -acetylhexosaminidase Am2136

Li, Chang-Cheng; Huan, Yi; Wang, Yan-Mei; Tang, Xinyue; Zhu, Yuanfeng; Song, Yingjie; Zhao, Ninglin; Huang, Qin; Mou, Xingyu; Luo, Guihua; Liu, Tonggen; Yang, Ganglong; Zeng, Yujiao; Wang, Li-Jie; Tang, Hong; Fan, Gang; Bao, Rui

doi:10.1080/19490976.2022.2143221

Cited by 1 publication

(1 citation statement)

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“…59 Recent research showed that Akkermansia pretreatment could inhibit Journal of Agricultural and Food Chemistry pubs.acs.org/JAFC Article extensive microglial activation and synaptic engulfment by increasing SCFA production. 60 Additionally, Akkermansia has also been reported to improve cognitive function by decreasing proinflammatory-associated pathways in both the peripheral blood and hippocampal profiles. 61 Several studies evidenced that desynchronization within and between peripheral clocks gastrointestinal tissues reduced microbial rhythmicity and caused an imbalance of SCFA fermentation.…”

Section: ■ Discussionmentioning

confidence: 99%

Gut Microbiota Mediate the Neuroprotective Effect of Oolong Tea Polyphenols in Cognitive Impairment Induced by Circadian Rhythm Disorder

Song,

Ho,

Zhang

2024

J. Agric. Food Chem.

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Oolong tea polyphenols (OTP) have attracted wide attention due to their ability to reduce inflammatory response, regulate gut microbiota, and improve cognitive function. However, exactly how the gut microbiota modulates nervous system activity is still an open question. We previously expounded that supplementing with OTP alleviated neuroinflammation in circadian rhythm disorder (CRD) mice. Here, we showed that OTP can relieve microglia activation by reducing harmful microbial metabolites lipopolysaccharide (LPS) that alleviate CRD-induced cognitive decline. Mechanistically, OTP suppressed the inflammation response by regulating the gut microbiota composition, including upregulating the relative abundance of Muribaculaceae and Clostridia_UCG-014 and downregulating Desulfovibrio, promoting the production of short-chain fatty acids (SCFAs). Moreover, the use of OTP alleviated intestinal barrier damage and decreased the LPS transport to the serum. These results further inhibited the activation of microglia, thus alleviating cognitive impairment by inhibiting neuroinflammation, neuron damage, and neurotoxicity metabolite glutamate elevation. Meanwhile, OTP upregulated the expression of synaptic plasticity-related protein postsynaptic density protein 95 (PSD-95) and synaptophysin (SYN) by elevating the brain-derived neurotrophic factor (BDNF) level. Taken together, our findings suggest that the OTP has the potential to prevent CRD-induced cognition decline by modulating gut microbiota and microbial metabolites.

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Section: ■ Discussionmentioning

confidence: 99%