Nucleotide Composition of the Genomic and Protein-Coding Sequences in the two DNA Strands

Abstract

Abstract-The nucleotide composition of protein-coding genes in the two DNA strands of Escherichia coli, Bacillus subtilis, Methanococcus jannaschii and mitochondrial genes of human and fruit fly was studied. E. coli, B. subtilis and M. jannaschii indicated compositional asymmetry in their genomic sequences. The protein-coding genes of E. coli and B. subtilis showed the influence of compositional asymmetry in their compositions, however, no influence was observed in M. jannaschii. Mitochondrial protein-coding genes showed significant difference in composition in the two DNA strands. The deviation of nucleotide composition in the two DNA strands is discussed.