Nucleotide sequence analysis of the <i>env</i>
 gene and its flanking regions of the human spumaretrovirus reveals two novel genes

doi:10.1002/j.1460-2075.1990.tb07594.x

The EMBO Journal

1990

DOI: 10.1002/j.1460-2075.1990.tb07594.x

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Nucleotide sequence analysis of the env gene and its flanking regions of the human spumaretrovirus reveals two novel genes

Abstract: In the above paper Fig. 1. The complete and correct bel 1 protein sequence of the human spumaretrovirus. Note that the corrected bel 1 protein has extensions at both the amino-and at the carboxy-terminus.

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Analysis of splicing patterns of human spumaretrovirus by polymerase chain reaction reveals complex RNA structures

Muranyi

Flügel

1991

J Virol

104

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Mapping of transcripts of the human foamy virus genome was carried out in permissive human embryonic fibroblast cells by Northern blot hybridization and Si nuclease analysis. Since several splice sites that are localized within a relatively narrow genomic region were detected, the polymerase chain reaction (PCR) was employed, and cloning and sequencing of the splice site junctions of the corresponding viral cDNAs were subsequently performed. All spumavirus transcripts have a common but relatively short leader RNA. Genomic, singly spliced env mRNAs and several singly and multiply spliced subgenomic transcripts were identified. The multiply spliced viral mRNAs consist of various exons located in the central or 3' part of the viral genome. At least four novel gene products, termed Bet, Bes, Beo, and Bel3, are predicted to exist. The poly(A) addition site that defines the boundary of the R and U5 region in the 3' long terminal repeat was determined. The pattern of spumavirus splicing is more complex than that of oncoviruses and more similar to that of lentiviruses. One of the characteristic features of spumavirus transcription is the existence of singly spliced bell and bell mRNAs that alternatively are multiply spliced, thereby generating a complexity comparable to, but different from, that of lentiviruses and from that of other known retroviruses. The complex spumavirus transcriptional pattern of human spumavirus and the coding potential of the 10 exons identified are discussed.

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Analysis of splicing patterns of human spumaretrovirus by polymerase chain reaction reveals complex RNA structures

Muranyi

Flügel

1991

J Virol

104

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Human foamy virus polypeptides: identification of env and bel gene products

Giron

Rozain

Debons-Guillemin

et al. 1993

J Virol

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Human foamy virus (HFV) proteins were identified in human cells cultured in vitro by immunoprecipitation and immunoblotting with specific antisera. Among several viral poypeptides, four glycoproteins of approximately 160, 130, 70, and 48 kDa were identified in HFV-infected ceUs. gpl30 was shown to represent the intracelular env precursor, and gp7O and gp48 were shown to represent the external and transmembrane env proteins, respectively. The nature of gp160, which shares sequences with the env, bell, and bel2 proteins, is not yet resolved. In addition, a p62 identified with belland bel2-specific antisera likely corresponds to the bet gene product.

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Nucleotide sequence analysis of the env gene and its flanking regions of the human spumaretrovirus reveals two novel genes

Abstract: In the above paper Fig. 1. The complete and correct bel 1 protein sequence of the human spumaretrovirus. Note that the corrected bel 1 protein has extensions at both the amino-and at the carboxy-terminus.

Cited by 2 publications

References 23 publications

Analysis of splicing patterns of human spumaretrovirus by polymerase chain reaction reveals complex RNA structures

Analysis of splicing patterns of human spumaretrovirus by polymerase chain reaction reveals complex RNA structures

Human foamy virus polypeptides: identification of env and bel gene products

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