Nucleotide sequence of feline immunodeficiency virus: classification of Japanese isolates into two subtypes which are distinct from non-Japanese subtypes

Kakinuma, Shizuko; Motokawa, Kenji; Hohdatsu, Tsutomu; Yamamoto, Janet K.; Koyama, Hiroyuki; Hashimoto, Hiroshi

doi:10.1128/jvi.69.6.3639-3646.1995

Cited by 109 publications

(61 citation statements)

References 28 publications

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“…1) have been established based on phylogenetic analyses of sequences from the env V3-V5 region (Sodora et al, 1994;Kakinuma et al, 1995;Pecoraro et al, 1996). Recent papers have also used the gag gene to confirm the env clades (Kakinuma et al, 1995;Duarte et al, 2002;Steinrigl and Klein, 2003;Reggeti and Bienzle, 2004;Weaver et al, 2004;Hayward and Rodrigo, 2008). Subtypes A, B and C are most widespread worldwide, with subtype D only found in Japan and Vietnam (Kakinuma et al, 1995;Nakamura et al, 2003) and subtype E only found in Argentina (Pecoraro et al, 1996).…”

Section: Fiv-fca Subtypesmentioning

confidence: 99%

Molecular epidemiology of feline immunodeficiency virus in the domestic cat (Felis catus)

Hayward

Rodrigo

2010

Veterinary Immunology and Immunopathology

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Studying the evolutionary mechanisms of feline immunodeficiency virus in the domestic cat (Felis catus), FIV Fca , provides a good comparison to other lentiviruses, such as HIV and FIV Pco in the cougar (Puma concolor). We review the current epidemiological and evolutionary findings of FIV Fca ,. In addition to the five accepted FIV Fca , subtypes, several recent phylogenetic studies have found strains that form separate clades, indicative of novel subtypes. In New Zealand cats, these strains of unknown subtype have been found to be involved in complex patterns of intergenic recombination, and whole genome sequences are required to resolve these. Evidence of recombination events has been documented with the highest levels in the env gene, the region involved in host cell receptor recognition. Several cases of FIV Fca , multiple infection, both interand intra-subtype, have been reported. The findings of both unknown subtypes and relatively high levels of recombination suggest the need for further testing of the current vaccine. Limited studies on the evolutionary rate of FIV Fca , document a value twice to three times that of FIV in the cougar, a result suggesting the different levels of co-adaptation between the viruses and their respective hosts. We studied the tissue distribution of FIV Fca , in feral domestic cats, finding the first case of FIV compartmentalisation, a phenomenon well-documented in HIV-1 patients.

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Section: Fiv-fca Subtypesmentioning

confidence: 99%

Molecular epidemiology of feline immunodeficiency virus in the domestic cat (Felis catus)

Hayward

Rodrigo

2010

Veterinary Immunology and Immunopathology

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“…For application of RNAi technology to therapeutic purposes of naturally FIV-infected cats, sequence diversity of FIV genome should be considered. The sequence used for preparation of G4-siRNA, which efficiently inhibited the replication of FIV in this study, is highly conserved among various strains of FIV (Kakinuma et al, 1995). Therefore, it is highly plausible that the siRNA such as G4 inhibits the replication of various field strains of FIVas well as Petaluma strain.…”

Section: Discussionmentioning

confidence: 91%

“…The design of siRNAs was based on general guidelines (Elbashir et al, 2001). Four siRNAs (G1, G2, G3, and G4) corresponding to gag gene of Petaluma FIV14 (Olmsted et al, 1989) (GenBank accession number: M25381) were chosen from the highly conserved sequence of FIV gag gene (Kakinuma et al, 1995) and synthesized (Dharmacon Research, Lafayette, CO). An siRNA (Luc) corresponding to the coding sequence of firefly luciferase was purchased from Dharmacon Research and used as a control.…”

Section: Preparation Of Sirnasmentioning

confidence: 99%

Application of RNA interference for inhibiting the replication of feline immunodeficiency virus in chronically infected cell lines

Baba

Mizukoshi

Goto‐Koshino

et al. 2007

Veterinary Microbiology

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RNA interference (RNAi) is a process in which double-stranded RNA induces the post-transcriptional sequence-specific degradation of homologous messenger RNA. The present study was carried out to apply the RNAi technology to inhibit the replication of feline immunodeficiency virus (FIV). Four small interfering RNAs (siRNAs) homologous to the FIV gag gene were synthesized and transfected into a feline fibroblastic cell line chronically infected with FIV (CRFK/FIV). These synthetic siRNAs efficiently inhibited the replication of FIV. Next, we examined the effect of retroviral vector-mediated transfer of FIV-specific short hairpin RNA (shRNA) on the replication of FIV in a feline T-cell line chronically infected with FIV (FL4). The retroviral vector-mediated transfer of FIV-specific shRNA was shown to markedly inhibit the replication of FIV in the FL4 cells. These results provide useful information for the development of RNAi-based gene therapy strategy to control FIV infection.

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“…FIV is present worldwide and can be classified into five well-characterised subtypes (A-E) [9][10][11][12][13]. The prevalence of FIV varies from 1% to 44%, depending on the health status of the investigated cats [3,[14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Virus–host interaction in feline immunodeficiency virus (FIV) infection

Taniwaki

Figueiredo

Araújo

2013

Comparative Immunology, Microbiology and Infectious Diseases

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Feline immunodeficiency virus (FIV) infection has been the focus of several studies because this virus exhibits genetic and pathogenic characteristics that are similar to those of the human immunodeficiency virus (HIV). FIV causes acquired immunodeficiency syndrome (AIDS) in cats, nevertheless, a large fraction of infected cats remain asymptomatic throughout life despite of persistent chronic infection. This slow disease progression may be due to the presence of factors that are involved in the natural resistance to infection and the immune response that is mounted by the animals, as well as due to the adaptation of the virus to the host. Therefore, the study of virus-host interaction is essential to the understanding of the different patterns of disease course and the virus persistence in the host, and to help with the development of effective vaccines and perhaps the cure of FIV and HIV infections.

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Nucleotide sequence of feline immunodeficiency virus: classification of Japanese isolates into two subtypes which are distinct from non-Japanese subtypes

Cited by 109 publications

References 28 publications

Molecular epidemiology of feline immunodeficiency virus in the domestic cat (Felis catus)

Molecular epidemiology of feline immunodeficiency virus in the domestic cat (Felis catus)

Application of RNA interference for inhibiting the replication of feline immunodeficiency virus in chronically infected cell lines

Virus–host interaction in feline immunodeficiency virus (FIV) infection

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