Nucleotide sequence of the genes for F0 components of the proton-translocating ATPase from  : Prediction of the primary structure of F0 subunits

Kanazawa, Hiroshi; Mabuchi, Kazunori; Kayano, Toshiaki; Noumi, Takato; Sekiya, Takao; Futai, Masamitsu

doi:10.1016/0006-291x(81)90495-2

Cited by 103 publications

(44 citation statements)

References 14 publications

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“…Accord- [8,10] and analyzed by SDSjpolyacrylamide gel eleetrophoresis. The order of the genes in the une operon and the eorrelation of genes with A TP-synthase subunits was established genetieally and by nucleotide sequenee analysis [1,[12][13][14][15][16][17][18][19][20][21][22][23]. The numbers below the genes indieate the number of amino acid residues in the subunit polypeptide.…”

Section: Background Problems and Approachesmentioning

confidence: 99%

“…The whole ATP synthase contains, in addition, the five F I subunits IX, ß, y, 8 and E. These eight subunit polypeptides are coded for by the eight genes that form the alp (une) operon (see section IV). The alp operon has been weIl defined geneticaIly, especially by Downie, et al [1,12], and by Von Meyenburg and co-workers [13], and its nucleotide sequence has been determined [14][15][16][17][18][19][20][21][22][23]. Therefore, the subunit composition of the ATP synthase and F o from E. eoli is proven.…”

Section: Background Problems and Approachesmentioning

confidence: 99%

“…The nucleotide sequence of the genes of all three F~ subunits of E. eoli was determined independently by three groups in 1981 [15,17,21]. Amino~terminal amino acid sequences of the isolated subunits a, b, and e were established [17] in order to prove the start of the individual subunit genes.…”

Section: Background Problems and Approachesmentioning

confidence: 99%

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The proton conducting F0-part of bacterial ATP synthases

Hoppe¹,

Sebald²

1984

Biochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics

228

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Section: Background Problems and Approachesmentioning

confidence: 99%

Section: Background Problems and Approachesmentioning

confidence: 99%

See 1 more Smart Citation

The proton conducting F0-part of bacterial ATP synthases

Hoppe¹,

Sebald²

1984

Biochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics

228

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“…A sequence homology was unexpectedly found between the repeating regions of OSCP (residues l-84) and the N-terminal part of the ADP/ATP carrier (residues 15-105) ( fig.4) [25]. The ADP/ ATP carrier is an integral protein of the inner mitochondrial membrane which exchanges cytoplasmic ADP for ATP synthesized inside the mitochondrion.…”

Section: Resultsmentioning

confidence: 99%

“…This part is in contact with the S-and CFsubunits, thus binding Fl to FO [7,12]. Comparative analysis of OSCP and the b-subunit [21,23,25] revealed a considerable homology between the repeating sequences of OSCP and the central part of the b-subunit (fig.3). The latter has been shown to contain repeated sequences [ 121.…”

Section: Resultsmentioning

confidence: 99%

Oligomycin sensitivity‐conferring protein (OSCP) of beef heart mitochondria

Ovchinnikov¹,

Modyanov²,

Grinkevich³

et al. 1984

FEBS Letters

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Structural analysis of oligomycin sensitivity~onferring protein (OSCP) revealed repeating sequences (residues l-89, 105-190) suggesting an evolution of the protein by gene duplication. In addition to the reported homology with the d-subunit of Escherichia coli F,ATPase, OSCP also shows a certain homology with the b-subunit of E. coli F,and the ADP/ATP carrier of mitochondria. Uhgomycin sensitivity-conferring protein Subunit Sequence homology Comparative analysisStructural relationship

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Membrane integration and function of the three F0 subunits of the ATP synthase of Escherichia coli K12.

Friedl¹,

Hoppe²,

Gunsalus³

et al. 1983

The EMBO Journal

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Integration into the cytoplasmic membrane and function of the three Fo subunits, a, b and c, of the membrane-bound ATP synthase of Escherichia coli K12 were analysed in situations where synthesis of only one or two types of subunits was possible. This was achieved by combined use of atp mutations and plasmids carrying and expressing one or two of the atp genes coding for ATP synthase subunits. An three Fo subunits were found to be required for the establishment of efficient H + conduction. Subunits a and b individually as well as together were found to bind F1 ATPase to the membrane while subunit c did not. The ATPase activity bound to either of these single subunits, or in pairwise combinations, was not inhibited by N,N '-dicyclohexylcarbodiimide. Also ATPdependent H + translocation was not catalysed unless all three Fo subunits were present in the membrane. The integration into the membrane of the subunits a and b was independent of the presence of other ATP synthase subunits.

show abstract

Nucleotide sequence of the genes for F0 components of the proton-translocating ATPase from : Prediction of the primary structure of F0 subunits

Cited by 103 publications

References 14 publications

The proton conducting F0-part of bacterial ATP synthases

The proton conducting F0-part of bacterial ATP synthases

Oligomycin sensitivity‐conferring protein (OSCP) of beef heart mitochondria

Membrane integration and function of the three F0 subunits of the ATP synthase of Escherichia coli K12.

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