Nucleotide sequence of the quail<i>c-jun</i>protooncogene

Brun, Gilbert; Vista, Nathalie La; Dangy, Jean Pierre; Castellazzi, Marc

doi:10.1093/nar/17.15.6393

Cited by 3 publications

(2 citation statements)

References 3 publications

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“…Immunoprecipitation with polyclonal antisera directed against recombinant Jun or Myc proteins or against Gag-related proteins was carried out with extracts from cells used for the Northern analyses shown in Figure 1. The analyses shown in Figure 2 revealed that normal QEF, QEF transfected with the empty RCAS retroviral vector, CEF or CEF infected with NK24, contained the normal low levels of endogenous quail or chicken c-Jun (313 amino acids, M r 34 341, or 310 amino acids, M r 33 940) (Brun et al, 1989;Nishimura and Vogt, 1988) or endogenous quail c-Myc (417 amino acids, M r 46 236) proteins with gelelectrophoretic mobilities corresponding to apparent molecular weights of 42 000 and 52 000, respectively. QEF transformed by the RCAS ± CJ3 or RCAS ± VJ1 constructs contained high levels of retrovirally speci®ed c-Jun (328 amino acids, M r 35 880, apparent molecular weight 42 000) or v-Jun (295 amino acids, M r 32 314, apparent molecular weight 36 000) proteins ( Figure 2A).…”

Section: Bkj Activation In ®Broblasts Is Also Induced By V-fosmentioning

confidence: 99%

Structure and transcriptional regulation of BKJ, a novel AP-1 target gene activated during jun- or fos-induced fibroblast transformation

Hartl

Bister

1998

Oncogene

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The BKJ gene was originally identi®ed based on its speci®c transcriptional activation in jun-transformed avian ®broblasts. We now show that BKJ is a direct transcriptional target of the AP-1 transcription factor components Jun and Fos. The complete structural organization of the quail BKJ gene was determined by nucleotide sequence analysis and transcriptional mapping. The gene contains three exons with the coding region con®ned to the third exon. A major mRNA species of 0.8 kb and a minor one of 1.3 kb are produced by variable usage of two transcriptional initiation sites. The BKJ promoter region contains two authentic AP-1 binding sites. By transactivation of reporter gene constructs and direct binding of Jun recombinant protein, the proximal AP-1 element was shown to be essential for BKJ promoter activation. Using polyclonal antiserum directed against recombinant BKJ protein, the activation of BKJ in jun-transformed avian ®broblasts was also demonstrated at the protein level. BKJ is a novel gene related to the avian b-keratin gene family whose members display highly speci®c expression patterns during embryogenesis and epidermal development. Activation of BKJ in ®broblasts by retroviral or deregulated cellular jun or fos alleles may contribute to cell transformation.

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Section: Bkj Activation In ®Broblasts Is Also Induced By V-fosmentioning

confidence: 99%

Structure and transcriptional regulation of BKJ, a novel AP-1 target gene activated during jun- or fos-induced fibroblast transformation

Hartl

Bister

1998

Oncogene

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“…Charged decays of the kaon were simulated with Geant4 [5] [6]. A list of selection criteria was sequentially applied to each event in the resulting Root [7] file. Events were eliminated if any of the following were true: a charged particle or photon was detected by the LAVs, IRC, or SAC; fewer than two energy clusters were detected by the LKr (clusters closer than 6 cm were merged); the reconstructed π 0 decayed outside of the fiducial region (105 < z < 155 m); an LKr cluster was closer than 35 cm to the beamline center; or the transverse momentum of the reconstructed π 0 was less than 0.12 GeV/c.…”

Section: Simulation and Analysismentioning

confidence: 99%

Evaluating the Charged Background Rejection Requirement in an Experiment to Measure BR(K_L→ π⁰νν^-)at the CERN SPS

Bradley

2016

J. Phys.: Conf. Ser.

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Measuring the rate at which the long-lived, neutral kaon decays into a neutral pion, neutrino, and anti-neutrino allows physicists an opportunity to test precise predictions made by the Standard Model. Differences between theoretical predictions and experimental measurements may point to new physics. Not only does the Standard Model predict a very low probability at approximately 3 KL → π 0 νν decays in 100 billion KL decays, but many of the common decays leave false signals in the detector that look the same as the true signal. Charged decays have been studied to determine the required detection efficiency necessary to eliminate them. The conclusion of these studies is that a reduction by a factor of 1/(3 × 10 9 ) will be required to achieve the 10:1 signal to charged background ratio necessary for the experiment.

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Expression of Cell-Cycle-Regulating Genes in the Development of Atherosclerosis in Japanese Quail (Coturnix japonica)

et al. 2007

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The levels of mRNA expression in regulatory genes that are involved in the pathological changes of aortic atherosclerotic and fibroblastic intimal thickening was investigated in Japanese quail. The quail were divided into a control diet group and an atherogenic diet group. The quail were euthanized at 2, 4, 8, and 12 wk after consuming either a control diet or an atherogenic diet. Thereafter, both histological and immunohistochemical studies and mRNA expression analysis of the cell-cycle-regulating genes in aortic atherosclerotic lesions were performed on selected ascending aortas and their large branches. In the atherogenic diet group, aortic lipid-containing intimal and atheromatous lesions were seen mainly at 8 and 12 wk, respectively. Semiquantitative reverse-transcription PCR was used to analyze the alterations of mRNA expression on the development of atherosclerotic lesions. Messenger RNA expression of the c-fos and c-src genes showed peak levels at 8 wk in the atherogenic diet group. However, no significant alteration of c-jun mRNA expression was noted during the entire experimental period. According to the progression of aortic atherosclerotic lesions, c-myc mRNA expression in the atherogenic diet group increased chronologically, and the highest level was observed at 12 wk. Alterations in mRNA expression of proliferating cell nuclear antigen and the p27 gene were similar to that of c-myc. The levels of c-myc, proliferating cell nuclear antigen, and p27 mRNA expression was significantly correlated with the degree of aortic atherosclerotic lesion development at 12 wk in our experiment.

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Nucleotide sequence of the quailc-junprotooncogene

Cited by 3 publications

References 3 publications

Structure and transcriptional regulation of BKJ, a novel AP-1 target gene activated during jun- or fos-induced fibroblast transformation

Structure and transcriptional regulation of BKJ, a novel AP-1 target gene activated during jun- or fos-induced fibroblast transformation

Evaluating the Charged Background Rejection Requirement in an Experiment to Measure BR(K_L→ π⁰νν^-)at the CERN SPS

Expression of Cell-Cycle-Regulating Genes in the Development of Atherosclerosis in Japanese Quail (Coturnix japonica)

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Nucleotide sequence of the quailc-junprotooncogene

Cited by 3 publications

References 3 publications

Structure and transcriptional regulation of BKJ, a novel AP-1 target gene activated during jun- or fos-induced fibroblast transformation

Structure and transcriptional regulation of BKJ, a novel AP-1 target gene activated during jun- or fos-induced fibroblast transformation

Evaluating the Charged Background Rejection Requirement in an Experiment to Measure BR(KL→ π0νν-)at the CERN SPS

Expression of Cell-Cycle-Regulating Genes in the Development of Atherosclerosis in Japanese Quail (Coturnix japonica)

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Evaluating the Charged Background Rejection Requirement in an Experiment to Measure BR(K_L→ π⁰νν^-)at the CERN SPS