Nucleotide sequence ofbup, an upstream gene in thebmi-1 proviral insertion locus

Abstract

The ability of Moloney murine leukemia virus to accelerate lymphomagenesis in E mu-myc transgenic mice is frequently associated with proviral integration within a locus denoted bmi-1. This locus contains not only the bmi-1 gene implicated as a collaborator with myc in lymphomagenesis but also just upstream an unknown gene denoted bup. The nucleotide sequence reported here for bup cDNA and flanking genomic sequences reveals that this widely expressed gene comprises at least 7 exons and potentially encodes a polypeptide of 195 amino acid residues. Computer searches with this polypeptide sequence revealed no close homolog in the databases, nor any conserved motifs, and it is unrelated to the product of the mel-13 gene, which lies just upstream from the bmi-1 homolog mel-18.

XIAP as a Molecular Target for Therapeutic Intervention in Prostate Cancer

“…COMMD6 is orthologous to a mouse gene located in a region that is necessary for normal embryonic development, although it is unclear whether COMMD6 itself is required for normal embryogenesis (31). Similarly, COMMD3 was previously identified as a locus with close proximity to the Polycomb-group gene Bmi-1 (32). Finally, an expressed sequence tag corresponding to COMMD7 was found to be consistently repressed in an experimental system designed to screen for factors involved in leukemogenesis (33).…”

The Polycomb group protein Enhancer of Zeste 2: its links to DNA repair and breast cancer

“…TrxG proteins act as epigenetic activators whereas PcG proteins act as epigenetic repressors. Fifteen years ago, PcG and TrxG proteins have been already described to be dysregulated in cells of hematopoietic neoplasms (Haupt et al 1991(Haupt et al , 1992Raaphorst et al 2000;Visser et al 2001). PcG proteins have been implicated in fundamental cellular processes such as cell fate and cell divisions, as well as in neoplastic transformation.…”