Nucleotide Therapy in Agranulocytosis

Why the History of Thyroid Disease Is Important

“…In his original description of this complication, Astwood discussed the use of pentnucleotide for the treatment of granuloctyopenia. Pentnucleotide was the accepted therapy for leukopenia from the 1910s until the 1950s (6,7). The drug helped define issues relating to the intellectual property of pharmaceutical products.…”

Agranulocytosis

“…This strengthens the view that the disease entity agranulocytic angina originates in the bone marrow and not in local sepsis. 3. The agranulocytic phase of the third case would probably be classified as agranulocytic aleukemic leukemia, with aplastic anemia.…”

Management of Skull Fractures and Intracranial Injuries

“…Yet Bailey, head of the department of neurosurgery at the University of Chicago, for years his assistant, frequently resorts to 4 In my opinion, both those who say that seldom or never should lumbar punctures be used and those who say they should be used as a routine are wrong. There is a middle ground, however : There are cases in which this procedure is definitely indicated and of the greatest value, but it should be used only in those cases.…”

“…4. If the average man will delay all roentgen exami¬ nations, undue physical examinations and operative procedures (with a rare exception) until the initial shock is over and then will classify his cases according to their signs and symptoms, he will develop for himself a common sense, rational line of treatment free from many of the controversial pitfalls commonly found in the management of skull fractures.…”