Nucleus accumbens dopamine receptors mediate the stress-induced analgesia in an animal model of acute pain

Noursadeghi, Elham; Rashvand, Mina; Haghparast, Abbas

doi:10.1016/j.brainres.2022.147887

Cited by 12 publications

(6 citation statements)

References 39 publications

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“…Additional studies on treadmill running have confirmed the D2R enhancement conferred by exercise ( 39–41 ). The increase of D2R-like binding as a result of exercise has also been suggested to attenuate aversion to pain and act as an analgesia ( 42 ). In this study, the D2R antagonist was only able to attenuate the pain-blocking response in the presence of the stressor of exercise.…”

Section: Introductionmentioning

confidence: 99%

High intensity interval training exercise increases dopamine D2 levels and modulates brain dopamine signaling

Tyler,

Podaras,

Richardson

et al. 2023

Front. Public Health

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BackgroundPrevious research has outlined the health benefits of exercise including its therapeutic potential for substance use disorders (SUD). These data have already been utilized and it is now common to find exercise as part of SUD treatment and relapse prevention programs. However, we need to better understand different exercise regimens and determine which would be the most beneficial for SUDs. Recently, high intensity interval training (HIIT) has gained attention in comparison with aerobic and resistance exercise. Little is known regarding the neurobiological mechanisms of HIIT, including its effects on dopamine signaling and receptor levels in the brain. The present study examined the effects of chronic HIIT exercise on dopamine signaling as measured by dopamine type 1-like receptor (D1R)-like, dopamine type 2-like receptor (D2R)-like, and tyrosine hydroxylase (TH) quantification in the brains of male and female rats as measured by [3H] SCH 23390 and [3H] spiperone autoradiography, and TH-immunoreactive optical density values.MethodsRats were separated in two groups: sedentary and HIIT exercise. Exercise was on a treadmill for 30 min daily (10 3 min cycles) for six weeks with progressive speed increased up to 0.8 mph (21.5 m/min).ResultsResults showed for D2R-like binding, a significant effect across the ventral caudate putamen (V CPU) between sexes, such that mean D2R-like binding was 14% greater for males than females. In the nucleus accumbens shell (Nac Shell), the HIIT Exercise rats showed 16% greater D2R-like binding as compared to the sedentary rats. No significant effects of HIIT exercise were found across groups for brain D1R-like binding levels or TH expression.ConclusionThese results suggest that HIIT exercise can modulate dopamine signaling by way of increased D2R. These findings support the premise that HIIT exercise plays an important role in dopamine signaling and, may provide a potential mechanism for how HIIT exercise can impact the brain and behavior.

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Section: Introductionmentioning

confidence: 99%

High intensity interval training exercise increases dopamine D2 levels and modulates brain dopamine signaling

Tyler,

Podaras,

Richardson

et al. 2023

Front. Public Health

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“…Prior studies, however, showed that stress is often considered a prominent nociception-involved player and exposure to particularly acute stress can be associated with decreased pain perception (al’Absi et al ., 2021). Similarly, prior studies confirmed that exposure to acute FSS attenuated nociceptive response, either in acute thermal pain or inflammatory pain models (Merdasi et al ., 2022; Noursadeghi et al ., 2022), and it is in line with the present study results, which showed acute FSS for 6 min reduced nociceptive response in the thermal acute pain model as well as inflammatory pain, via dopamine receptors.…”

Section: Discussionmentioning

confidence: 99%

“…SCH23390 hydrochloride (C17H18ClNO.HCl) as a selective D1R antagonist and (RS)-(±)-sulpiride (C15H23N3O4S) as a D2R antagonist were purchased from Tocris Bioscience, Bristol, United Kingdom. Following the product datasheets, SCH23390 was dissolved in the doses of 0.25, 1, and 4 µg/0.5 µl normal saline (pH 6.9), and sulpiride was dissolved in the doses of 0.25, 1, and 4 µg/µl dimethyl sulfoxide (DMSO) 12% (pH 6.7) (Merdasi et al ., 2022; Noursadeghi et al ., 2022). Additionally, either normal saline or DMSO 12%, as vehicles of SCH 23390 or sulpiride, respectively, were used in the vehicle control groups.…”

Section: Methodsmentioning

confidence: 99%

“…Briefly, the mentioned apparatus applies an acute thermal pain, through a focused light stimulus, on the dorsal surface of the animal’s tail, and an automatic sensor detects and records the time of latency for the tail-withdrawal reflex. Notably, the light intensity source had been manually set at 45% of the maximum volume, resulting in baseline tail-flick latency (TFL) values in the mean range of 3–4 s. Additionally, a cutoff time point had been also equaled 10 s to avoid tail tissue damage (Askari et al ., 2021; Mazaheri et al ., 2022; Noursadeghi et al ., 2022).…”

Section: Methodsmentioning

confidence: 99%

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D2-like dopamine receptors blockade within the dentate gyrus shows a greater effect on stress-induced analgesia in the tail-flick test compared to D1-like dopamine receptors

Golmohammadi,

Shirmohammadi,

Mazaheri

et al. 2024

Behavioural Pharmacology

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Introduction Acute stress, as a protective mechanism to respond to an aversive stimulus, can often be accompanied by suppressing pain perception via promoting consistent burst firing of dopamine neurons. Besides, sensitive and advanced research techniques led to the recognition of the mesohippocampal dopaminergic terminals, particularly in the hippocampal dentate gyrus (DG). Moreover, previous studies have shown that dopamine receptors within the hippocampal DG play a critical role in induced antinociceptive responses by forced swim stress (FSS) in the presence of inflammatory pain. Since different pain states can trigger various mechanisms and transmitter systems, the present experiments aimed to investigate whether dopaminergic receptors within the DG have the same role in the presence of acute thermal pain. Methods Ninety-seven adult male albino Wistar rats underwent stereotaxic surgery, and a stainless steel guide cannula was unilaterally implanted 1 mm above the DG. Different doses of SCH23390 or sulpiride as D1- and D2-like dopamine receptor antagonists were microinjected into the DG 5–10 min before exposure to FSS, and 5 min after FSS exposure, the tail-flick test evaluated the effect of stress on the nociceptive response at the time-set intervals. Results The results demonstrated that exposure to FSS could significantly increase the acute pain perception threshold, while intra-DG administration of SCH23390 and sulpiride reduced the antinociceptive effect of FSS in the tail-flick test. Discussion Additionally, it seems the D2-like dopamine receptor within the DG plays a more prominent role in FSS-induced analgesia in the acute pain model.

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“…On the other hand, VTA dopaminergic neurons project to the amygdala, NAc, prefrontal cortex, and hippocampus [for review, see (Douma and de Kloet, 2020)]. Dopamine receptors in the NAc (Noursadeghi et al , 2022) and DG region of the hippocampus (Merdasi et al , 2022), nicotinic acetylcholine receptors of the ventral hippocampus (Ghasemzadeh and Rezayof, 2015), and the cannabinoid CB1 receptors in the basolateral amygdala (Connell et al , 2006) participate in the SIA.…”

Section: Discussionmentioning

confidence: 99%

The modulatory role of dopamine receptors within the hippocampal cornu ammonis area 1 in stress-induced analgesia in an animal model of persistent inflammatory pain

Dezfouli

Merdasi

Rashvand

et al. 2022

Behavioural Pharmacology

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The intrinsic pain inhibitory mechanisms can be activated by fear, anxiety, and stress. Stressful experiences produce analgesia, referred to as stress-induced analgesia (SIA). Major components of the limbic system, including the ventral tegmental area, nucleus accumbens, amygdala, and hippocampus, are involved in the SIA. In this study, we tried to understand the role of dopamine receptors in the cornu ammonis area 1 (CA1) of the hippocampus in the forced swim stress (FSS)-induced analgesia. Stereotaxic surgery was unilaterally performed on 129 adult male Wistar rats weighing 220–280 g. SCH23390 (0.25, 1, and 4 μg/0.5 μl saline) or sulpiride (0.25, 1, and 4 μg/0.5 μl DMSO), as D1- and D2-like dopamine receptor antagonists, respectively, were microinjected into the CA1 area, 5 min before exposure to FSS for a 6-min period. The vehicle groups received saline or DMSO instead of SCH23390 or sulpiride, respectively. The formalin test was done using formalin injection (50 μl; 2.5%) into the plantar surface of the rat’s hind paw immediately after exposure to FSS. The results demonstrated that FSS produces analgesia during the early and late phases of the formalin test. However, intra-CA1 microinjection of SCH23390 or sulpiride attenuated the FSS-induced analgesia in both phases of the formalin test. This study provides new insight into the role of D1- and D2-like dopamine receptors in the CA1 area in the FSS-induced analgesia during persistent inflammatory pain.

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Nucleus accumbens dopamine receptors mediate the stress-induced analgesia in an animal model of acute pain

Cited by 12 publications

References 39 publications

High intensity interval training exercise increases dopamine D2 levels and modulates brain dopamine signaling

High intensity interval training exercise increases dopamine D2 levels and modulates brain dopamine signaling

D2-like dopamine receptors blockade within the dentate gyrus shows a greater effect on stress-induced analgesia in the tail-flick test compared to D1-like dopamine receptors

The modulatory role of dopamine receptors within the hippocampal cornu ammonis area 1 in stress-induced analgesia in an animal model of persistent inflammatory pain

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