Nucleus basalis Meynert lesions and the expression of nicotinic acetylcholine receptor proteins in the rat frontal cerebral cortex

Altered Sigma-1 Receptor Expression in Two Animal Models of Cognitive Impairment

“…This data indicates that most sigma-1 receptors in the parietal cortex are located postsynaptically, and their expression is increased as a consequence of cortical cholinergic hypofunction. Similar findings were reported for muscarinic m2/m4 receptors in the parietal cortex [31] and for the alpha4 isoform of nicotinic receptors in the frontal cortex [32,33], 1 week after nucleus basalis lesioning.…”

“…If sigma-1 receptor changes parallel those of nicotinic receptors, their upregulation may be transient. The expression of cortical nicotinic alpha4 receptors is increased 1 week after the lesion procedure, but returns to baseline after 4 weeks [32,33].…”