Nucleus basalis prosencephali, a substrate of apomorphine-induced pecking in pigeons

Lindenblatt, Ulrike; Delius, Juan D.

doi:10.1016/0006-8993(88)90137-0

Cited by 17 publications

(17 citation statements)

References 34 publications

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“…Remarkably, Apo injections into the Acc did not have any effect on the same discriminatory performance of the pigeons, even at a high dose ( Table 3). The Acc of birds is assumed to receive a significant dopaminergic input from the midbrain tegmentum, and Apo administered elsewhere (systemically or cerebrally) is known to elicit stereotypies and to act rewardingly in pigeons (20,35). However, it is possible that the additional dopaminergic Acc stimulation due to Apo injection did not add significantly to the normal dopamine drive.…”

Section: Discussionmentioning

confidence: 99%

Visual Discrimination in Pigeons Impaired by Glutamatergic Blockade of Nucleus Accumbens

Gargiulo

Siemann

Delius

1998

Physiology & Behavior

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The nucleus accumbens septi (Acc) is thought to be involved in the control of cognitive processes and to be implicated in the pathophysiology of schizophrenia. Because perceptual-cognitive distortions are a core symptom in schizophrenia, any evidence that the Acc intervenes in a sensory recognition task in an animal species would be of interest. Pigeons were instrumentally trained to discriminate visual shapes. The acute effects of drug microinjections into the Acc on the discrimination of the training shapes, on the correction responding after errors, and on the generalisation to different shapes were examined. The effects of conduction blockade with lidocaine, glutamatergic blockade with 7-aminophosphonoheptanoic acid, and dopaminergic stimulation with apomorphine on behavioural performance were tested. No effects were observed with lidocaine and apomorphine. A significant and reversible performance disruption to near chance levels was obtained after aminophosphonoheptanoic acid injections into the Acc. It appears that a glutamatergic blockade of the Acc interferes with the visual discrimination processes of pigeons.

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Section: Discussionmentioning

confidence: 99%

Visual Discrimination in Pigeons Impaired by Glutamatergic Blockade of Nucleus Accumbens

Gargiulo

Siemann

Delius

1998

Physiology & Behavior

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“…Apomorphine-induced pecking fits are accompanied by an increase of glucose uptake in the nucleus basalis 18 and intracranial apomorphine injections into this structure induce stereotypical pecking bouts. 54 Therefore, nucleus basalis was thought to be a central element of apomorphine triggered pecking stereotypies and to possess dopamine receptors. 18 This last assumption was strengthened by the finding of Wynne and Delius 102 that nucleus basalis lesions significantly reduce pecking fits after apomorphine injection.…”

Section: Distribution Of Darpp-32mentioning

confidence: 99%

The dopaminergic innervation of the pigeon telencephalon: distribution of DARPP-32 and co-occurrence with glutamate decarboxylase and tyrosine hydroxylase

et al. 1998

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Abstract--Dopaminergic axons arising from midbrain nuclei innervate the mammalian and avian telencephalon with heterogeneous regional and laminar distributions. In primate, rodent, and avian species, the neuromodulator dopamine is low or almost absent in most primary sensory areas and is most abundant in the striatal parts of the basal ganglia. Furthermore, dopaminergic fibres are present in most limbic and associative structures.Herein, the distribution of DARPP-32, a phosphoprotein related to the dopamine D1-receptor, was investigated in the pigeon telencephalon by immunocytochemical techniques. Furthermore, co-occurrence of DARPP-32-positive perikarya with tyrosine hydroxylase-positive pericellular axonal ''baskets'' or glutamate decarboxylase-positive neurons, as well as co-occurrence of tyrosine hydroxylase and glutamate decarboxylase were examined. Specificity of the anti-DARPP-32 monoclonal antibody in pigeon brain was determined by immunoblotting. The distribution of DARPP-32 shared important features with the distribution of D1-receptors and dopaminergic fibres in the pigeon telencephalon as described previously. In particular, DARPP-32 was highly abundant in the avian basal ganglia, where a high percentage of neurons were labelled in the ''striatal'' parts (paleostriatum augmentatum, lobus parolfactorius), while only neuropil staining was observed in the ''pallidal'' portions (paleostriatum primitivum). In contrast, DARPP-32 was almost absent or present in comparatively lower concentrations in most primary sensory areas. Secondary sensory and tertiary areas of the neostriatum contained numbers of labelled neurons comparable to that of the basal ganglia and intermediate levels of neuropil staining. Approximately up to one-third of DARPP-32-positive neurons received a basket-type innervation from tyrosine hydroxylasepositive fibres in the lateral and caudal neostriatum, but only about half as many did in the medial and frontal neostriatum, and even less so in the hyperstriatum. No case of colocalization of glutamate decarboxylase and DARPP-32 and no co-occurrence of glutamate decarboxylase-positive neurons and tyrosine hydroxylase-basket-like structures could be detected out of more than 2000 glutamate decarboxylase-positive neurons examined, although the high DARPP-32 and high tyrosine hydroxylase staining density hampered this analysis in the basal ganglia.In conclusion, the pigeon dopaminergic system seems to be organized similar to that of mammals. Apparently, in the telencephalon, dopamine has its primary function in higher level sensory, associative and motor processes, since primary areas showed only weak or no anatomical cues of dopaminergic modulation. Dopamine might exert its effects primarily by modulating the physiological properties of non-GABAergic and therefore presumably excitatory units. 1998 IBRO. Published by Elsevier Science Ltd.Key words: DARPP-32, dopamine, D1 receptor, glutamate decarboxylase, tyrosine hydroxylase, pigeon, immunocytochemistry.The mesotelencephalic dopaminergic syst...

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“…The increase in glucose utilization in the ventral medial pallium might also result from the action of APO as a positive reinforcer [e.g. see also Baxter et al, 1974;Cools et al, 1977;Schiff, 1982;Woolverton et al, 1984;Müller et al, 1987;Lindenblatt and Delius, 1988;Burg et al, 1989;Wynne and Delius, 1995]. We suggest that the resulting medial pallial output, in concert with APO-enhanced influences from dopaminergic cells of the ventral tegmental area stimulates the nucleus accumbens and the hypothalamus which, with the nucleus of the solitary tract, then influence the reticular/branchiomotor/hypoglossal system to lower the threshold for snap behavior generation ( fig.…”

Section: Apo-induced Facilitation Of Snappingmentioning

confidence: 99%

Apomorphine Alters Prey-Catching Patterns in the Common Toad: Behavioral Experiments and <sup>14</sup>C-2-Deoxyglucose Brain Mapping Studies

Glagow

Ewert²

1999

Brain Behav Evol

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Previous studies on the dopaminergic modulation of visuomotor functions in amphibians showed that the dopamine agonist apomorphine (APO) alters prey-catching strategies. After systemic administration of APO in common toads Bufo bufo, prey-oriented turning and locomotion was attenuated whereas snapping toward prey was facilitated in a dose dependent manner. With systemic APO administration, toads which had previously been hunting, that is pursuing prey, behaved in a waiting position, that is sitting motionless and waiting for prey. This suggests that APO facilitates the ingestive component and inhibits the orientational and locomotory components of prey capture. To help unravel the cerebral sites of action of APO, the present study employs the ¹⁴C-2-deoxyglucose method to compare the rate of local glucose utilization in 41 brain structures. The retinal projection fields – e.g. superficial optic tectum, pretectal nuclei, and anterior dorsal thalamic nucleus – showed an elevation in glucose utilization due to APO-induced increases in retinal output. The medial tectal layers and the ventral striatum, both involved in visuomotor functions related to prey-oriented turning and locomotion, displayed APO-induced decreases in glucose utilization. APO-induced increases in glucose utilization were observed in the medial reticular formation and the hypoglossal nucleus which participate in the motor pattern generation of snapping. APO-induced increases in glucose utilization were also detected in the nucleus accumbens and the ventral tegmentum (mesolimbic system) as well as in the ventromedial pallium (‘primordium hippocampi’) and the septum, both of which belonging to the limbic system. These structures contribute to motivational level control and may be responsible for the APO-induced elevation of the snapping rate. Various other structures revealed APO-induced increases in glucose utilization. These structures include the olfactory bulb, lateral pallium, suprachiasmatic nucleus, nucleus of the periventricular organ, and the nucleus of the solitary tract. The lateral amygdala displayed APO-induced decreases in glucose utilization. The APO-induced alterations in local cerebral glucose utilization are evaluated with reference to the distribution of dopaminergic structures, and this is compared with similar data obtained in the rat by other authors. A neural network explaining the APO-induced behavioral syndrome in the common toad is discussed.

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Nucleus basalis prosencephali, a substrate of apomorphine-induced pecking in pigeons

Cited by 17 publications

References 34 publications

Visual Discrimination in Pigeons Impaired by Glutamatergic Blockade of Nucleus Accumbens

Visual Discrimination in Pigeons Impaired by Glutamatergic Blockade of Nucleus Accumbens

The dopaminergic innervation of the pigeon telencephalon: distribution of DARPP-32 and co-occurrence with glutamate decarboxylase and tyrosine hydroxylase

Apomorphine Alters Prey-Catching Patterns in the Common Toad: Behavioral Experiments and <sup>14</sup>C-2-Deoxyglucose Brain Mapping Studies

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