Nucleus reuniens of the thalamus contains head direction cells

Jankowski, Maciej M.; Islam, Nurul; Wright, Nicholas Fraser; Vann, Seralynne Denise; Erichsen, Jonathan Thor; Aggleton, John Patrick; O’Mara, Shane M.

doi:10.7554/elife.03075

Cited by 104 publications

(96 citation statements)

References 21 publications

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“…Next to a relatively small percentage of cells with diverse spatial properties, the vast majority of RE neurons (~64%) appeared to be low frequency firing cells without spatial properties, of which approximately 17% fired only at frequencies below 1 Hz (Jankowski et al 2014). Thus low frequency stimulation of RE, as applied in this study, appears to mimic the physiological properties of a large group of RE neurons.…”

Section: Functional Relevancementioning

confidence: 56%

“…Recent studies in freely-moving rats have shed some light on the physiological properties of RE neurons (Jankowski et al 2014(Jankowski et al , 2015. Next to a relatively small percentage of cells with diverse spatial properties, the vast majority of RE neurons (~64%) appeared to be low frequency firing cells without spatial properties, of which approximately 17% fired only at frequencies below 1 Hz (Jankowski et al 2014).…”

Section: Functional Relevancementioning

confidence: 99%

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Interaction of nucleus reuniens and entorhinal cortex projections in hippocampal field CA1 of the rat

Weel

Silva

2016

Brain Struct Funct

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The nucleus reuniens (RE) and entorhinal cortex (EC) provide monosynaptic excitatory inputs to the apical dendrites of pyramidal cells and to interneurons with dendrites in stratum lacunosum-moleculare (LM) of hippocampal field CA1. However, whether the RE and EC inputs interact at the cellular level is unknown. In this electrophysiological in vivo study, low frequency stimulation was used to selectively activate each projection at its origin; field excitatory postsynaptic potentials (fEPSPs) were recorded in CA1. We applied 1) paired pulses to RE or EC, 2) combined paired pulses to RE and EC, and 3) simultaneously paired pulses to RE/EC. The main findings are that: i) stimulation of either RE or EC evoked subthreshold fEPSPs, displaying paired pulse facilitation (PPF), ii) subthreshold fEPSPs evoked by combined stimulation did not display heterosynaptic PPF, and iii) simultaneous stimulation of RE/EC resulted in enhanced subthreshold fEPSPs in proximal LM displaying a nonlinear interaction.CSD analyses of RE/EC-evoked depth profiles revealed a nonlinear enlargement of the 'LM sink-radiatum source' configuration and the appearance of an additional small sink-source pair close to stratum pyramidale, likely reflecting (peri)somatic inhibition. The nonlinear interaction between both inputs indicates that RE and EC axons form synapses, at least partly, onto the same dendritic compartments of CA1 pyramidal cells. We propose that low frequency activation of the RE-CA1 input facilitates the entorhinal-hippocampal dialogue, and may synchronize the neocortical-hippocampal slow oscillation which is relevant for hippocampal-dependent memory consolidation.

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Section: Functional Relevancementioning

confidence: 56%

Section: Functional Relevancementioning

confidence: 99%

Interaction of nucleus reuniens and entorhinal cortex projections in hippocampal field CA1 of the rat

Weel

Silva

2016

Brain Struct Funct

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“…Recent data also suggest the presence of a population of head-direction cells in the nucleus reuniens of the thalamus (Jankowski et al, 2014). The nucleus reuniens head-direction cells are similar to the head-direction cells of the anterodorsal and anteroventral thalamic nuclei, lateral mammillary nucleus (Taube, 2007), and some parahippocampal regions.…”

Section: Integration Of Internal Idiothetic and External Sensory Signalsmentioning

confidence: 80%

“…1). Nucleus reuniens sends a strong excitatory projection to hippocampal formation (Vertes et al, 2007), thus offering yet another route by which thalamic activity may also modulate hippocampal signal processing (Jankowski et al, 2014). Further research is needed to investigate whether the vestibular signal in nucleus reuniens is a parallel or alternative to anterior thalamus directional information.…”

Section: Integration Of Internal Idiothetic and External Sensory Signalsmentioning

confidence: 99%

Decoding signal processing in thalamo-hippocampal circuitry: implications for theories of memory and spatial processing

Tsanov

O’Mara

2015

Brain Research

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a b s t r a c tA major tool in understanding how information is processed in the brain is the analysis of neuronal output at each hierarchical level through which neurophysiological signals are propagated. Since the experimental brain operation performed on Henry Gustav Molaison (known as patient H.M.) in 1953, the hippocampal formation has gained special attention, resulting in a very large number of studies investigating signals processed by the hippocampal formation. One of the main information streams to the hippocampal formation, vital for episodic memory formation, arises from thalamo-hippocampal projections, as there is extensive connectivity between these structures. This connectivity is sometimes overlooked by theories of memory formation by the brain, in favour of theories with a strong corticohippocampal flavour. In this review, we attempt to address some of the complexity of the signals processed within the thalamo-hippocampal circuitry. To understand the signals encoded by the anterior thalamic nuclei in particular, we review key findings from electrophysiological, anatomical, behavioural and computational studies. We include recent findings elucidating the integration of different signal modalities by single thalamic neurons;we focus in particular on the propagation of two prominent signals: head directionality and theta rhythm. We conclude that thalamo-hippocampal processing provides a centrally important, substantive, and dynamic input modulating and moderating hippocampal spatial and mnemonic processing. This article is part of a Special Issue entitled SI: Brain and Memory.& 2014 Published by Elsevier B.V. IntroductionThe purpose of the present review is to dissect some of the complexity of the signals propagated from anterior thalamus to the hippocampal formation in order to try and understand the importance of this information processing for the coding properties of individual neurons in the hippocampus. "Anterior thalamus" includes the anterodorsal, anteroventral and dorsolateral thalamic nuclei, which form the thalamic component of the limbic system (the 'thalamic

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“…1). There have been reports of HD cells beyond the classical HD circuitry in the lateral dorsal thalamic nucleus (Mizumori and Williams, 1993), the striatum (Mizumori et al, 2000;Wiener, 1993), medial precentral cortex (Mizumori et al, 2005), and more recently within the anteroventral thalamic nucleus (Tsanov et al, 2011a) and nucleus reuniens ( Jankowski et al, 2014). The proportion of HD cells within each brain region varies, with the largest proportion found in the ADN.…”

Section: Hd Cellsmentioning

confidence: 99%