Nucleus targeting anthraquinone-based copper (II) complexes as the potent PDT agents: Synthesis, photo-physical and theoretical evaluation

Devi, L. Reena; Raza, Kausar; Musib, Dulal; Ramu, Vanitha; Devi, J Renuka; Roy, Mithun

doi:10.1016/j.ica.2019.119208

Cited by 18 publications

(16 citation statements)

References 64 publications

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“…Two years later, the same team designed complexes with remarkable cytotoxicity upon visible light irradiation (IC 50 values of 2–11 μM), thanks – once again – to the increased photosensitization with S-coordination and to the addition of an anthraquinone moiety ( Cu-11 ). 128 The in-the-dark cytotoxicity is significantly reduced (IC 50 value of >50 μM in HeLa cells) contrarily to most other Cu( ii ) complexes. Cu-11 possess a reduction potential ( E 1/2 = −0.46 V) far beyond the biological redox window, therefore inhibiting the reduction of the Cu( ii ) complex, which might explain this relatively low dark cytotoxicity.…”

Section: Phototoxic First-row Transition Metal Complexesmentioning

confidence: 97%

Phototherapeutic anticancer strategies with first-row transition metal complexes: a critical review

2022

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Section: Phototoxic First-row Transition Metal Complexesmentioning

confidence: 97%

Phototherapeutic anticancer strategies with first-row transition metal complexes: a critical review

2022

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“…The singlet oxygen generation results in the inactivation of DNA repair enzymes as well as breaking DNA strands in nuclei ( Ling et al, 2012 ). Based on these two important damage mechanisms, targeting the hypersensitive nuclei is considered as an important component of PDT ( Devi et al, 2020 ; Wan et al, 2020 ). Shi et al synthesized TAT and RGD (R: arginine, G: glycine, D: aspartic acid) peptides which are conjugated to mesoporous silica nanoparticles (MSNs).…”

Section: Novel Approaches To Improve Outcomementioning

confidence: 99%

Photodynamic Therapy—Current Limitations and Novel Approaches

2021

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Photodynamic therapy (PDT) mostly relies on the generation of singlet oxygen, via the excitation of a photosensitizer, so that target tumor cells can be destroyed. PDT can be applied in the settings of several malignant diseases. In fact, the earliest preclinical applications date back to 1900’s. Dougherty reported the treatment of skin tumors by PDT in 1978. Several further studies around 1980 demonstrated the effectiveness of PDT. Thus, the technique has attracted the attention of numerous researchers since then. Hematoporphyrin derivative received the FDA approval as a clinical application of PDT in 1995. We have indeed witnessed a considerable progress in the field over the last century. Given the fact that PDT has a favorable adverse event profile and can enhance anti-tumor immune responses as well as demonstrating minimally invasive characteristics, it is disappointing that PDT is not broadly utilized in the clinical setting for the treatment of malignant and/or non-malignant diseases. Several issues still hinder the development of PDT, such as those related with light, tissue oxygenation and inherent properties of the photosensitizers. Various photosensitizers have been designed/synthesized in order to overcome the limitations. In this Review, we provide a general overview of the mechanisms of action in terms of PDT in cancer, including the effects on immune system and vasculature as well as mechanisms related with tumor cell destruction. We will also briefly mention the application of PDT for non-malignant diseases. The current limitations of PDT utilization in cancer will be reviewed, since identifying problems associated with design/synthesis of photosensitizers as well as application of light and tissue oxygenation might pave the way for more effective PDT approaches. Furthermore, novel promising approaches to improve outcome in PDT such as selectivity, bioengineering, subcellular/organelle targeting, etc. will also be discussed in detail, since the potential of pioneering and exceptional approaches that aim to overcome the limitations and reveal the full potential of PDT in terms of clinical translation are undoubtedly exciting. A better understanding of novel concepts in the field (e.g. enhanced, two-stage, fractional PDT) will most likely prove to be very useful for pursuing and improving effective PDT strategies.

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“…Using adopted scheme, a series of new anthraquinone derivatives were prepared. The described approach opens up access to several derivatives of based on anthraquinones, which can be extended for the preparation of class of compounds for different applications (Cardoso et al, 2019;Devi et al, 2020;Li et al, 2017;Nagia and El-Mohamedy, 2007;Orbán et al, 2008;Penthala et al, 2019;Ramotowska et al, 2019;Rybczyńska-Tkaczyk et al, 2018;Shan et al, 2015;Tapeinou et al, 2018;Veremeichik et al, 2019;Zarren et al, 2019;.…”

Section: Resultsmentioning

confidence: 99%

Facile route for the synthesis and characterization of new naphtho[2,3-f]quinoxaline-dione, trione and anthra-dione derivatives

Int¹

2019

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In the present study, addition of nitroso group at position 1 of 2-aminoanthraquinone (1) to yield 2-amino-1-nitroanthraquinone (2) was carried out by the reaction of compound (1) with sodium nitrite in water. Compound (2) was used as starting material to produce many new naphtho[2,3-f] quinoxaline-dione, trione, naphtho-pyrazole quinoxaline-dione, anthra-triazine-dione, naphtho-thiazole quinoxaline-dione and anthrabenzo-triazepine-dione derivatives by elimination of one molecule of water as an initial reaction step. The reacting moieties were nitroso and amino function groups to yield a series of compounds. The structures of the products were determined by elemental mass, IR and 1H NMR analysis and the adopted method is efficient to prepare a series of compounds and could possibly be used for the synthesis of new compounds.

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Nucleus targeting anthraquinone-based copper (II) complexes as the potent PDT agents: Synthesis, photo-physical and theoretical evaluation

Cited by 18 publications

References 64 publications

Phototherapeutic anticancer strategies with first-row transition metal complexes: a critical review

Phototherapeutic anticancer strategies with first-row transition metal complexes: a critical review

Photodynamic Therapy—Current Limitations and Novel Approaches

Facile route for the synthesis and characterization of new naphtho[2,3-f]quinoxaline-dione, trione and anthra-dione derivatives

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