NUDT21 Promotes Tumor Growth and Metastasis Through Modulating SGPP2 in Human Gastric Cancer

Zhu, Yong; Zhang, Rumeng; Zhang, Ying; Cheng, Xiao; Li, Lin; Wu, Zhengsheng; Ding, Keshuo

doi:10.3389/fonc.2021.670353

Cited by 7 publications

(7 citation statements)

References 40 publications

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“…Zheng [ 23 ] found that NUDT21 was a valuable marker in the prognosis of pancreatic ductal adenocarcinoma and can promote tumor proliferation and inhibit apoptosis through EIF2 signaling. Zhu [ 18 ] proved that the significant expression of NUDT21 in GC cells promotes tumor cell growth and metastasis by upregulating SGP2 in nude mice. Lou [ 24 ] demonstrated that the NF-kB inhibitor zeta (NFKBIZ) was a downstream target of NUDT21, and that MES recognition genes CHI3L1 and FN1 were differentially regulated in glioblastoma cells.…”

Section: Discussionmentioning

confidence: 99%

“…According to reports, NUDT21 has dual carcinogenic and inhibitory effects in cancer [ 12 ]. Current studies have demonstrated that NUDT21 regulates bladder cancer [ 13 ], hepatocellular carcinoma [ 14 ], glioblastoma [ 15 ], leukemia [ 16 ], breast cancer [ 17 ], and gastric cancer [ 18 ]. Justin Brumbaugh identified NUDT21 as a novel post-transcriptional regulator of cell fate, and in alternative polyadenylation and established a direct link between chromatin signaling [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

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Pan-cancer analysis of NUDT21 and its effect on the proliferation of human head and neck squamous cell carcinoma

Liu,

Pang,

et al. 2024

Aging

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Background: Based on bioinformatics research of NUDT21 in pan-cancer, we aimed to clarify the mechanism of NUDT21 in HHNC by experiment. Methods: The correlation between differential expression of NUDT21 in pan-cancer and survival prognosis, genomic instability, tumor stemness, DNA repair, RNA methylation and with immune microenvironment were analyzed by the application of different pan-cancer analysis web databases. In addition, immunohistochemistry staining and genetic detection of NUDT21 in HHNCC tumor tissues by immunohistochemistry and qRT-PCR. Then, through in vitro cell experiments, NUDT21 was knocked down by lentivirus to detect the proliferation, cycle, apoptosis of FaDu and CNE-2Z cells, and finally by PathScan intracellular signaling array reagent to detect the apoptotic protein content. Results: Based on the pan-cancer analysis, we found that elevated expression of NUDT21 in most cancers was significantly correlated with TMB, MSI, neoantigens and chromosomal ploidy, and in epigenetics, elevated NUDT21 expression was strongly associated with genomic stability, mismatch repair genes, tumor stemness, and RNA methylation. Based on immunosuppressive score, we found that NUDT21 plays an essential role in the immunosuppressive environment by suppressing immune checkpointing effect in most cancers. In addition, using HHNSCC as a study target, PCR and pathological detection of NUDT21 in tumor tissues was significantly increased than that in paracancerous normal tissues. In vitro cellular assays, silencing NUDT21 inhibited proliferation and promoted apoptosis in FaDu and CNE-2Z cells, and blocked the cell cycle in the G2/M phase. Therefore, the experiments confirmed that NUDT21 promotes the proliferation of FaDu by suppressing the expression of apoptotic.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pan-cancer analysis of NUDT21 and its effect on the proliferation of human head and neck squamous cell carcinoma

Liu,

Pang,

et al. 2024

Aging

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“…It has been reported that Nudix hydrolase 21 promotes tumor growth and metastasis through modulating SGPP2 in gastric cancer. ( Zhu et al, 2021 ). TMEM200C is reported to be hypomethylated, and candidate oncogenes linked to early metastasis in uveal melanoma.…”

Section: Discussionmentioning

confidence: 99%

Recurrence Risk of Liver Cancer Post-hepatectomy Using Machine Learning and Study of Correlation With Immune Infiltration

et al. 2021

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Postoperative recurrence of liver cancer is the main obstacle to improving the survival rate of patients with liver cancer. We established an mRNA-based model to predict the risk of recurrence after hepatectomy for liver cancer and explored the relationship between immune infiltration and the risk of recurrence after hepatectomy for liver cancer. We performed a series of bioinformatics analyses on the gene expression profiles of patients with liver cancer, and selected 18 mRNAs as biomarkers for predicting the risk of recurrence of liver cancer using a machine learning method. At the same time, we evaluated the immune infiltration of the samples and conducted a joint analysis of the recurrence risk of liver cancer and found that B cell, B cell naive, T cell CD4+ memory resting, and T cell CD4+ were significantly correlated with the risk of postoperative recurrence of liver cancer. These results are helpful for early detection, intervention, and the individualized treatment of patients with liver cancer after surgical resection, and help to reveal the potential mechanism of liver cancer recurrence.

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“…Last year Zhu et al. published that NUDT21 promoted cell proliferation, colony formation, cell migration and invasion through modulating SGPP2 in human gastric cancer ( 101 ). They found that NUDT21 expression was positively correlated with tumor size, lymph node metastasis and clinical stage in gastric cancer patients.…”

Section: Nudt21 and Apa And Tumormentioning

confidence: 99%

Relationship between NUDT21 mediated alternative polyadenylation process and tumor

Xiao

Gu²,

Deng³

et al. 2023

Front. Oncol.

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Alternative polyadenylation (APA) is a molecular process that generates diversity at the 3’ end of RNA polymerase II transcripts from over 60% of human genes. APA and microRNA regulation are both mechanisms of post-transcriptional regulation of gene expression. As a key molecular mechanism, Alternative polyadenylation often results in mRNA isoforms with the same coding sequence but different lengths of 3’ UTRs, while microRNAs regulate gene expression by binding to specific mRNA 3’ UTRs. Nudix Hydrolase 21 (NUDT21) is a crucial mediator involved in alternative polyadenylation (APA). Different studies have reported a dual role of NUDT21 in cancer (both oncogenic and tumor suppressor). The present review focuses on the functions of APA, miRNA and their interaction and roles in development of different types of tumors.NUDT21 mediated 3’ UTR-APA changes can be used to generate specific signatures that can be used as potential biomarkers in development and disease. Due to the emerging role of NUDT21 as a regulator of the aforementioned RNA processing events, modulation of NUDT21 levels may be a novel viable therapeutic approach.

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NUDT21 Promotes Tumor Growth and Metastasis Through Modulating SGPP2 in Human Gastric Cancer

Cited by 7 publications

References 40 publications

Pan-cancer analysis of NUDT21 and its effect on the proliferation of human head and neck squamous cell carcinoma

Pan-cancer analysis of NUDT21 and its effect on the proliferation of human head and neck squamous cell carcinoma

Recurrence Risk of Liver Cancer Post-hepatectomy Using Machine Learning and Study of Correlation With Immune Infiltration

Relationship between NUDT21 mediated alternative polyadenylation process and tumor

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