Numb chin syndrome: a case series and discussion

Divya, Kakarla; Moran, Nirupama; Atkin, Philip A.

doi:10.1038/sj.bdj.2010.157

Cited by 25 publications

(22 citation statements)

References 15 publications

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“…The aetiologies of NCS include local dental causes causing direct injury, infiltration by systemic malignancies or amyloidosis, inflammatory pathologies like systemic vasculitides and infections inflicting the inferior alveolar or mental nerves 6. Ever since the first description of NCS by Charles Bell in a case of metastatic breast carcinoma,7 this syndrome has been increasingly recognised as a harbinger for serious systemic malignancies.…”

Section: Discussionmentioning

confidence: 99%

Numb chin syndrome as a presenting symptom of diffuse large B-cell lymphoma with secondary myelofibrosis

2018

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Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin's lymphoma that classically presents with rapidly enlarging lymph nodes. We present a 59-year-old man with unusual clinical presentation of numb chin syndrome (NCS) as the first symptom of disease. On evaluation, he was found to have diffuse extranodal skeletal involvement in the form of lytic-sclerotic lesions and minimal lymphadenopathy. Bone marrow biopsy revealed a poorly differentiated tumour with infarction and extensive myelofibrosis. This was subsequently proven to be DLBCL of germinal centre type on immunohistochemical stain. NCS should alarm the clinician to investigate for an advanced underlying malignancy. Extensive myelofibrosis, though described in carcinomas and low grade lymphomas, may also be seen in high grade DLBCL.

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Section: Discussionmentioning

confidence: 99%

Numb chin syndrome as a presenting symptom of diffuse large B-cell lymphoma with secondary myelofibrosis

2018

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“…To our knowledge, this is the fi rst described case of numb chin syndrome as an initial presentation of malignancy in a transplant patient. It is still unclear how specifi c this clinical sign is for malignancy, the exact mechanism of eff ect on the mental nerve, if this sign is associated with a worse prognosis of malignancy, or if identifi cation of a malignancy based on diagnostic workup done because of this sign would aff ect survival (16,17).…”

Section: Discussionmentioning

confidence: 99%

Numb Chin Syndrome as the Initial Presentation of Posttransplant Lymphoproliferative Disorder

Shahriar¹,

Alexander²,

Quirk³

et al. 2012

Baylor University Medical Center Proceedings

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“…However, the pathophysiology of mental neuropathy provides evidence that vascular changes and secondary osseous changes appear in patients with systemic arteritides. Mental neuropathy, is caused by a variety of factors, like infections, dental pathology, sickle-cell anemia, diabetes mellitus, amyloidosis, perineural spread, sarcoidosis, metastases [15,16]. Many of these factors, affect the vasa nervorum of the epineurium of the mental nerve.…”

Section: Vascular Pathology and Osseous Changesmentioning

confidence: 99%