Number of parity is associated with low-grade albuminuria in middle-aged and elderly Chinese women

Sun, Kan; Lin, Diaozhu; Feng, Qiling; Li, Feng; Qi, Yiqin; Feng, Wei; Ren, Meng; Yan, Li; Liu, Dan

doi:10.1186/s12905-019-0814-2

Cited by 3 publications

(4 citation statements)

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“…The biomarkers of cardiovascular disease are also higher owing to parity. A gradual increase in low-grade albuminuria (protein in urine, a marker of an increased risk of cardiovascular health problems) with parity was observed in women from China [42]. Giving birth early (at less than 20 years of age) also contributes to a greater overall cardiovascular risk in older age [43].…”

Section: Does Reproduction Have a Long-term Negative Impact? Health And Age-related Diseasesmentioning

confidence: 99%

“…Parity is related to increased body weight. In China, women with high parity had an increased BMI, waist circumference, systolic blood pressure, fasting plasma glucose and insulin, and decreased high-density lipoprotein cholesterol [42]. In British women, the number of children was positively associated with a BMI and waist–hip ratio [44].…”

Section: Does Reproduction Have a Long-term Negative Impact? Health And Age-related Diseasesmentioning

confidence: 99%

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Costs of reproduction and ageing in the human female

Jasieńska

2020

Phil. Trans. R. Soc. B

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Evolutionary theories of ageing point to reproduction as a significant factor to consider when asking why ageing occurs and why there is inter-individual variation in its progression. Reproduction in human females is costly, in terms of energy, nutrients and metabolic adjustments. Thus, it is expected that women who experienced high reproductive effort resulting from multiple reproductive events will age faster. However, the evidence for long-term negative effects of reproduction is not conclusive. The lack of understanding of whether there are trade-offs between reproduction and ageing in women is partly due to methodological challenges. The costs of reproduction are often calculated based only on parity, while other elements contributing to these costs (e.g. breastfeeding, timing of reproduction) are neglected, which may significantly underestimate the total costs and obscure the all-important inter-individual variation in such costs. Costs must be evaluated in relation to individual characteristics, including developmental conditions, nutritional status and social support that a mother receives during reproduction. Furthermore, ageing and health must be assessed based on comprehensive markers rather than arbitrarily assembled variables. Finally, longitudinal rather than cross-sectional studies and new statistical approaches are needed to reveal how much of a decline in health and progressing ageing can actually be attributed to past reproductive processes. This article is part of the theme issue ‘Evolution of the primate ageing process'.

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Section: Does Reproduction Have a Long-term Negative Impact? Health And Age-related Diseasesmentioning

confidence: 99%

Section: Does Reproduction Have a Long-term Negative Impact? Health And Age-related Diseasesmentioning

confidence: 99%

Costs of reproduction and ageing in the human female

Jasieńska

2020

Phil. Trans. R. Soc. B

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“…Some studies suggested that parity was remarkably associated with the risk of carotid atherosclerotic plaque, and also associated with a decrease of HDL-C and an increase of the ratio of blood glucose/insulin [ 20 , 21 ]. In addition, multiple parturition could increase the risk of metabolic syndrome in women, and thus, it might result in the increased risk of ICVD in postmenopausal women to a certain extent [ 22 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

Research on risk factors of ischemic cerebrovascular disease in postmenopausal women based on the social-ecological model

Yang

Wang

et al. 2022

Eur J Med Res

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Objective Based on the social-ecological model, this study aimed to comprehensively explore factors affecting the risk of ischemic cerebrovascular disease (ICVD) in postmenopausal women to provide theoretical bases for further prevention and intervention for postmenopausal women. Methods Postmenopausal women who underwent medical examinations in one health-checkup agency in Tianjin from May 2015 to October 2015 were enrolled in this study. The ICVD 10-year Risk Assesment Form developed by the research team of the National "Tenth Five-Year Plan" research project was used to assess the factors affecting the risk of ICVD. Based on the social-ecological model, multiple types of scales, including physical activities, depression, Type D personality, social supports, and environment score, were used to comprehensively explore the factors associated with ICVD in postmenopausal women. Results 300 valid questionnaires were obtained, with an effective rate of 92.0%. The subjects aged 44–74 years, with the average age of 62.06 ± 7.09 years. Among them, 58.67% of the subjects only obtained high-school diploma, 32.67% obtained college or university diploma, 90.33% were retirees, 95.33% were married, 92.33% experienced the natural menopause, 93.33% lived in urban or suburban areas, and 1.00% had a history of breast cancer. Multivariate logistic regression analysis suggested that monthly income (¥), parity, exposure to second-hand or third-hand smoke, easy access to healthy food, physical activities, depression, Type D personality, social support and environmental factors were associated with the risk of ICVD in postmenopausal women (P < 0.05). Among them, easy access to healthy food (OR = 0.242), social support (OR = 0.861) and environmental factors (OR = 0.866) were protective factors from ICVD. OR < 1 indicates that the exposure factor is negatively correlated with the disease, and the exposure factor has a protective effect on preventing the occurrence of the disease. Parity (OR = 3.795), exposure to second-hand or third-hand smoke (OR = 2.886), depression (OR = 1.193), and Type D personality (OR = 1.148) were risk factors of ICVD. OR > 1 means that the exposure factor is positively correlated with the disease, and the exposure factor increases the risk of disease occurrence. Conclusions For postmenopausal women, in the future, in addition to prevention and management of the conventional risks, the conditions of their mentality and social support should be paid attention to, at the same time, and if they can, try to choose a good community environment to live in, which could better reduce the incidence and mortality of ICVD in postmenopausal women.

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“…The multivariate logistic analysis revealed that the OR values of parity, exposure to second (third)-hand smoke, depression, and Type D personality were 3.795 (95%CI: 1.657-8.689), 2.886 (95%CI: 1.087~7.659), 1.193 (95% CI: 1.072~1.328), and 1.148 (95%CI: 1.044~1.264), respectively, which were all risk factors for ICVD in postmenopausal women. Some studies suggested that parity was remarkably associated with the risk of carotid atherosclerotic plaque, and also associated with a decrease of HDL-C and an increase of the ratio of blood glucose/insulin (20,21). In addition, multiple parturition could increase the risk of metabolic syndrome in women, and thus, it might result in the increased risk of ICVD in postmenopausal women to a certain extent (22,23).…”

Section: Analysis Of Factors Affecting the Risk Of Icvd In Postmenopa...mentioning

confidence: 99%

Research on Factors Affecting the Risk of Ischemic Cerebrovascular Disease in Postmenopausal Women Based on the Social-Ecological Model

Yang

Wang

et al. 2022

Preprint

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Objective Based on the social-ecological model, this study aimed to comprehensively explore factors affecting the risk of ischemic cerebrovascular disease (ICVD) in postmenopausal women to provide theoretical bases for further prevention and intervention for postmenopausal women. Methods Postmenopausal women who underwent medical examinations in one health-checkup agency in Tianjin from May 2015 to October 2015 were enrolled in this study. The ICVD 10-year Risk Assesment Form developed by the research team of the National "Tenth Five-Year Plan" research project was used to assess the factors affecting the risk of ICVD. Based on the social-ecological model, multiple types of scales were used to comprehensively explore the factors associated with ICVD in postmenopausal women. Results 300 valid questionnaires were obtained, with an effective rate of 92.0%. The maximum age of the subjects was 74 years old, the minimum age was 44 years old, and the average age was 62.06 ± 7.09 years old. Among them, 58.67% of the subjects only obtained high-school diploma, 32.67% obtained college or university diploma, 90.33% were retirees, 95.33% were married, 92.33% experienced the natural menopause, 93.33% lived in urban or suburban areas, and 1.00% had a history of breast cancer. Multivariate logistic regression analysis suggested that monthly income, parity, exposure to second-hand or third-hand smoke, easy access to healthy food, physical activities, depression, Type D personality, social support and environmental factors were associated with the risk of ICVD in postmenopausal women (P < 0.05). Among them, easy access to healthy food (OR = 0.242), social support (OR = 0.861) and environmental factors (OR = 0.866) were the protective factors from ICVD. Parity (OR = 3.795), exposure to second-hand or third-hand smoke (OR = 2.886), depression (OR = 1.193), and Type D personality (OR = 1.148) were risk factors of ICVD. Conclusions For postmenopausal women, in the future, in addition to prevention and management of the conventional risks, the conditions of their mentality and social support should be paid attention to, at the same time, and if they can, try to choose a good community environment to live in, which could better reduce the incidence and mortality of ICVD in postmenopausal women.

show abstract

Number of parity is associated with low-grade albuminuria in middle-aged and elderly Chinese women

Cited by 3 publications

References 37 publications

Costs of reproduction and ageing in the human female

Costs of reproduction and ageing in the human female

Research on risk factors of ischemic cerebrovascular disease in postmenopausal women based on the social-ecological model

Research on Factors Affecting the Risk of Ischemic Cerebrovascular Disease in Postmenopausal Women Based on the Social-Ecological Model

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